Search results for " fluid"
Article
What’s New in Upstream Technologies
The sensor is packaged with its own calibration fluid, which gives it a two-year shelf life. Wet, one-point standardization before startup allows for the sensor’s characteristics and functionality to …
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Understanding Validation and Technical Transfer, Part 3
Then the cells are collected, washed, and resuspended in a fluid such as lactated Ringer’s. Depending on the process, intermediates may be frozen or refrigerated prior to onward processing. There are …
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Understanding Validation and Technical Transfer, Part I
From 1970-1973, a series of septicemia events in hospitals throughout the United States due to contaminated IV fluids were linked to inadequate container-closure systems and terminal sterilization con…
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Reducing Cross-Contamination Risks in Process Chromatography
“The obvious advantage with single-use technology is that it provides a replaceable fluid path that eliminates the risk of cross-contamination between different molecules,” he notes.
In a…
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Immediate, Flexible Capacity with Hydrated Buffers and Process Liquids
However, trends suggested buffer fluid preparation is one area seeing increase activity in outsourcing, as it reduces bottlenecks and is a low risk and alternative way to increase capacity. Download n…
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Design and Qualification of Single-Use Systems
• Fluid contact properties that should be considered in product design include chemical compatibility (e.g., polymer solubility, swelling, embrittlement, etc.), chemical reactivity, extractables under…
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Host-Cell Protein Measurement and Control
In a typical recovery process for a therapeutic monoclonal antibody, the highest concentration of HCP is detected in the harvested cell culture fluid (HCCF), and then cleared through additional downst…
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Detecting Protein Aggregates and Evaluating their Immunogenicity
…, and intrinsic particles (such as silicone droplets), according to Lew Brown, technical director at Fluid Imaging Technologies. New technologies for protein characterization tell us more about parti…
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Tackling Analytical Method Development for ADCs
Bioanalysis in biological fluids
From an immunoassay perspective, the development and validation of methods for the bioanalysis of ADCs require the consistent availability of high affinity, high s…
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HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
Samples containing antibodies in cell culture fluid were injected onto a Protein A column for antibody recovery, then the purified antibody sample was automatically injected onto the size exclusion co…