Search results for " 3D modeling" in Articles / App Notes
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Newer classes of biotherapies will require innovations in processing technology.
By Glen R. Bolton, Bernard N. Violand, Richard S. Wright, Shujun Sun, Khurram M. Sunasara, Kathleen Watson, Johna…
Article
In silico optimization of AAV full/empty particle separation with AIEX
The separation of adeno-associated virus (AAV) with high yield and purity is an increasingly important challenge. Mechanistic modeling is the tool of choice to find the optimal AIEX chromatogr…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
In this interview, Jakob Liderfelt, Product Manager at Cytiva, discusses main challenges faced during chromatography process development for mAbs and mAb variants such as fragments and bispecific a…
Article
HTPD 2023 conference is coming up. What will be discussed and what happened last time?
The 6th international conference devoted to high-throughput process development (HTPD) and smart process development (PD) will take place on October 31 – November 2 in Valletta, Malta.
A…
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Digitalized PD: Speeding up downstream process development
Mechanistic models enable the simulation of chromatography processes based on fundamental natural laws, such as fluid dynamics and thermodynamics. In silico simulations of chromatography proce…
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Top Process Development Trends for 2022 and a Look into 2023
FDA approved 37 drugs in 2022, within the normal range for the past decade or so. The European Medicines Agency (EMA) was even more successful—approving a record 55 therapies. More than half of thes…
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Simulating chromatography processes in the growing molecular diversity
The increasing complexity and diversity of development pipelines poses new challenges for product manufacturing. Mechanistic modeling can play a key role in overcoming these challenges as they…
Article
Tools and methodologies for smarter downstream process development
Scibetta
Smart process development is a collection of approaches to improve process outcomes and speed up process development.
In this video, John Scibetta, Advanced Chromatogra…
Article
Accelerating VLP purification process development
See how using mechanistic modeling can speed up the purification process development of virus-like particles (VLPs).
Indeed, a method for the large-scale production of VLPs is produ…
Article
Updating Viral Clearance for New Biologic Modalities
Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.
By Feliza Mirasol
Ensuring viral clearance (i.e., removal) in downstream purification has becom…