Search results for " continuous"
Article
What Drove Biopharma Development in 2014?
In 2014, there was significant increased interest in continuous processing, both upstream and downstream. On the PDF site, this trend was evident based on webinar invitations, as well as in published …
Article
Pharma Investments Reflect Key Industry Trends
…it would invest a further $330 million on additional upgrades and a new technology center focused on continuous manufacturing, biocatalysis, nanotechnology, and supply-chain processes. The company al…
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Regulatory Challenges in the QbD Paradigm
Under this paradigm, manufacturers have extensive knowledge about product, process, and quality attributes and strive for continuous improvement to reach the desired end point of consistent, safe and …
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Quality by design for biotechnology products—part 1
The QbD approach can be maintained throughout the lifecycle of the product to facilitate innovation and continuous improvement based on expanded knowledge and new technologies. This knowledge is gaine…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Finally, Kellerhals observes that technology and human ingenuity go hand in hand when striving for continuous improvement. He also emphasizes that “the evolution of sterility standards over time to wh…
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A Closer Look at Affinity Ligands
Affinity ligands play an exciting role in the ever-growing sphere of downstream processing. In speaking with BioPharm International®, Phillip Elliott, PhD, associate director of Process Development,…
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Setting Up Bioprocessing Systems for Digital Transformation
Bioprocessing is no exception, as the industry continuously seeks to improve large-scale commercial production of traditional biologics, in addition to seeking innovative ways to meet the bioprocessin…
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Strategizing for Rapid Changeovers in Biologics Manufacturing
In addition, a quality risk management approach may be applied to assess and continuously improve established changeover processes, according to Nestola. “All processes, including changeovers, can be …
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Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
The increase in titers and the trend toward continuous biomanufacturing will lead to increased demand in buffer volumes and prep times. To address this gap, strategies for improving mAb manufacturing …
Article
Gene Therapies Push Viral Vector Production
In addition, the growth factors need to be continuously and manually added/replenished in the medium. This cumbersome process leads to an increase in the chances of errors.
• Cell expansion …