Search results for " perfusion" in Articles / App Notes

Article Automating Bioprocesses
There are several licensed products that use a continuous perfusion process upstream, but downstream continuous processing is still evolving. The control strategy and automation are important in conti…

Article Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
Advances in cell culture media technology have helped achieve safer biologics. By Tom Fletcher, Holden Harris Regulatory expectations for cell-culture-based biologics production processes ch…

Article Managing Biomanufacturing Capacity Expectations
Despite these benefits, concentrated fed-batch used more perfusion and feed media, required numerous filters, and also overloaded downstream processes, causing filter fouling in some cases. The yields…

Article Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Figure is courtesy of Cytiva  Starting with upstream, the status of the cell line and whether the process should be batch, fed-batch, or perfusion needs to be decided. Details about the nature of…

Article Biopharma in 2015: A Year for Approvals and Innovations
…raphy in downstream processing of a monoclonal antibody Highly efficient inoculum propagation in perfusion culture using WAVE Bioreactor™ systems The Use of Dynamic Control in Periodic Counter…

Article Biopharma Advances Demand Specialized Expertise
…Lorimer (Patheon Biologics): Continuous production from mammalian cell cultures has been operated in perfusion bioreactors for many years. The main roadblock for continuous processing is downstream p…

Article Continuous Chromatography: Trends, Definitions and Approaches
Obviously, prevention of bioreactor contamination is of paramount importance if the reactor is operated in perfusion mode and is connected to a continuous chromatography system, but this can be realiz…

Article What Drove Biopharma Development in 2014?
On the PDF site, this trend was evident based on webinar invitations, as well as in published application notes and articles, such as Highly efficient inoculum propagation in perfusion culture using W…

Article The Future of Biopharma
…tion of single-use systems at clinical and commercial scale • continuous processing, including perfusion • high-tech expression systems and other genetic engineering advances • automation…

Article Addressing the Challenges in Downstream Processing Today and Tomorrow
Cell culture was performed using numerous methods, including roller bottles and stirred tank bioreactors operated in perfusion, batch re-feed, or fed-batch mode (1).  Starting in 1986 with the lic…

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