Search results for "htpd" in Articles / App Notes
Article
High-Throughput Process Development in Biopharma
During early process development, high-throughput process development (HTPD):
• Shortens development time
• Increases the amount of information available
• Enables reduction of sample a…
Article
Q&A with Eric Langer, about the evolution of the role of CMO’s in Bioprocessing
This week Process Development Forum speaks with Eric Langer, President and Managing Partner at BioPlan Associates, and the author of a number of biopharma studies, about the role of CMO’s in Bioproc…
Article
Optimization of a HIC step for recombinant protein purification
Follow this step-by-step high-throughput process development (HTPD) workflow to determine the optimal resin and initial conditions for hydrophobic interaction chromatography (HIC).
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Article
Utilization of Mechanistic Modeling to Improve Process Development
Mechanistic modeling was also one of the most discussed topics at the recent HTPD conference in Toledo, Spain. An extended report from the conference has now been completed with 15 different presentat…
Article
Development of Purification for Challenging Fc-Fusion Proteins
Using a combination of high-throughput process development (HTPD) in a 96-well batch binding format and small-scale column optimization experiments in a flow-through mode, the authors have developed a…
Article
High-Throughput Process Development Handbook
High-throughput process development (HTPD) shortens development time at the same time as it increases the amount of information available during early process development. Evaluating chromatographic c…
Article
Q&As with Industry Leaders
…rtner at BioPlan Associates
3rd HTPD Conference
Phil Lester, Co-Organizer of the HTPD Conference
…
Article
Developing a HIC polishing step for removal of mAb aggregates
It includes:
- The use of HTPD plates to select the optimal resin as well as running conditions
- The use of a design of experiments (DoE) to optimize the running conditions
- A Monte Carlo simul…
Article
How to Use Multiwell Plates With Manual Operation
During process development, aspects like robustness, scalability, and GMP production come into play. FDA initiatives such as quality by design (QbD) put demands on better process understan…
Article
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