Search results for " therapeutic"
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Evaluation of HEK293 Cell Growth and Adenovirus Productivity in HyClone™ CDM4HEK293 Medium
HEK293 cells are susceptible to infection by adenovirus, one of the most frequently used viral vectors in the development of therapeutic vaccines and vaccines against infectious diseases. This applica…
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Bioburden Control in the Biopharmaceutical Industry
Conclusion
The biologics sector is continually expanding because these drugs demonstrate better therapeutic value in treating an increasing number of chronic diseases (18). Biologics manufacturing…
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Contract Manufacturing Through the Years
Finally, the impact of new therapeutic and manufacturing technologies bears close attention. New targeted therapies mean that the average volume per product is declining; even when more sophisticated …
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Hybrid Bioprocessing: A Q&A with Andrew Sinclair
In the therapeutic protein space, there has not been a truly SU facility at commercial scale.
What could be the main reasons and/or the main drivers that hybrid bioprocessing are being used? Is th…
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Improvements in Protein A Chromatography
Bolton recently published a paper “Role of more than 40 years of improvement in Protein A chromatography in the growth of the therapeutic antibody industry,” and also presented at the spring ACS meeti…
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Mechanistic Modeling of Preparative Ion-Exchange Chromatography
This specificity is of particular relevance to the production of biotech therapeutics, which require high standards of purity. However, development and optimization of a process chromatography step pr…
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Drug Quality Key to Innovation and Access
These issues were highly visible in the debate over FDA approval of Sarepta Therapeutics’ treatment for Duchenne muscular dystrophy; reviewers and senior staffers in the Center for Drug Evaluation and…
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A Platform Approach to Purification of Antibody Fragments
As compared with full length antibodies, their fragments have unique properties that make them favorable for certain therapeutic conditions. However, due to their high molecular diversity, the use of …
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Generating a Fully Processed Antibody
If a modifying enzyme is required in the process, a sufficient level of the enzyme is needed to fully modify the therapeutic protein; however, too much expression may affect cell growth or other cell …
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Affinity Chromatography Handbook: Vol. 1 Antibodies
The diversity of the antibody-antigen interaction and our ability to manipulate the characteristics of the interaction has created many uses for antibodies and antibody fragments, both for immunoche…