Search results for " therapeutic"
Article
Commercial Production of Gene Therapies Using Suspension or Adherent Cell Lines
The rise of therapeutic monoclonal antibodies (mAbs) in the 1980s drove the requirement to adapt Chinese hamster ovary (CHO) cells to suspension in order to allow the use of stirred tank bioreactor fo…
Article
Setting Up Bioprocessing Systems for Digital Transformation
Meanwhile, for therapeutic applications, processes need to be run to current good manufacturing practice (CGMP) standards, and tend to be designed to not have many decision points, to aid with complia…
Article
Common Challenges in Cross-Functional Process Development
…opment and quality that encompasses early process development to commercial operations for all major therapeutic classes.
Topic covered include:
1:28 – Common stumbling blocks in develo…
Article
Future Downstream Process Development Solutions for Advanced Therapies
Related Content
Q&As with Industry Leaders
mRNA manufacturing strategies
Manufacturing of viral vectors
Purification of plasmids
Oligonucleotide therapeutics
Article
Remote Monitoring and Big Data Advance Upstream Automation
New therapeutic modalities, most notably personalized medicines, also present unique automation challenges that cannot be solved using more traditional batch monoclonal antibody automation systems. “L…
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
Commercially available PAT solutions that will fuel the rise of intensified processing of therapeutic proteins are limited in number, however. Close collaboration between vendors, manufacturers, and h…
Article
Process Development: 2020 Reflections and 2021 Possibilities
Moving from optional to essential bioprocess components, one process the industry often relies on for the cost-effective production of therapeutics is process chromatography, particularly for monoclon…
Article
Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
More than 70 FlexFactory installations around the world are already in use for clinical trials and commercial production of advanced and novel therapeutics and vaccines. The FlexFactory, designed for …
Article
Advancements in Antibody Purification
Learn more and register here >>
The demand for more efficient and agile downstream purification processes for diversified therapeutic antibody pipelines requires the development of new…
Article
Cytiva Introduces the Xcellerex Automated Perfusion System
“Simplifying upstream bioprocess workflows is one way we deliver on Cytiva’s mission to advance and accelerate therapeutics,” said Olivier Loeillot, senior vice-president BioProcess, Cytiva, in the pr…