Search results for " aggregation"
Article
Ensuring Viral Safety of Viral Vaccines and Vectors
Moreover, conditions should be adjusted to avoid aggregation or complex formation of therapeutic viruses and, thus, product loss.
Chromatographic methods are potentially effective tools for adv…
Article
ADC Development Robust Despite Lackluster Performance
Because its polymer is highly water soluble, it can be used to surround the cytotoxic payload and compensate for the payload’s poor solubility, thus minimizing aggregation and maintaining the ADC’s st…
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
When establishing purification processes for a biosimilar molecule it is important to develop steps that are scalable, selective, and cost-effective.
A cation exchange (CIEX) chromatographic ste…
Article
Best Practices for Data Integrity
Best Practices for Data Integrity
Optimize practices and meet requirements using electronic data integrity systems.
By Jennifer Markarian
Maintainin…
Article
Managing Residual Impurities During Downstream Processing
Increased understanding of potential impurities has spurred efforts to standardize monitoring procedures.
By Cynthia A. Challener
Manufacture of protein and other biologic drug substances via …
Article
Downstream Processing for Cell-Based Therapies
By Qasim A. Rafiq, Fernanda Masri
With increasing numbers of advanced therapies—including cell and gene therapies—entering early- and late-stage clinical development, significant focus has been …
Article
Process Chromatography Selection for Downstream Processing Applications
Industry experts discuss best practices for selecting a separation technology.
By Caroline Hroncich
Process chromatography has changed significantly since it was first introduced to the biop…
Article
Perfusion in the 21st Century
Constantly removing the product from the bioreactor reduces the retention time of the protein, a key improvement under production conditions that facilitate aggregation and degradation of the biologic…
Article
Selecting the Right Viral Clearance Technology
…grity of the protein product, which can be a challenge because physiochemical methods can induce the aggregation, fragmentation, or other undesired effects on some molecules. It is essential to have …
Article
Automated harvesting and 2-step purification of unclarified mammalian cell-culture broths containing antibodies
Therapeutic monoclonal antibodies represent one of the fastest growing segments in the pharmaceutical market. The growth of the segment has necessitated development of new efficient and cost saving …