Search results for "virus"
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Technology Innovations Improve Process Chromatography Performance
Convective flow membrane chromatography and monoliths addressed the previous purification challenges with diffusive matrices for large molecules, such as viruses (> 100 nm), plasmids, or even large pr…
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New Therapies Present Scaling Challenges
The genetic material to be introduced into the mammalian cell include the DNA that encodes the cell’s machinery to make the virus, which will be the vehicle through which the therapy is delivered, and…
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Addressing the Complex Nature of Downstream Processing with QbD
These steps are typically designed with more specific product attributes in mind and need more fine-tuning to achieve a goal of product or process related impurity or virus reduction,” says MacDonald.…
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Development of Purification for Challenging Fc-Fusion Proteins
In this study, utilizing a combination of high-throughput condition screening in 96-well plates, optimization in small-scale column models, and a novel virus-spiking strategy, the authors have develop…
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Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
But because the chosen methods focused primarily on downstream virus removal or inactivation instead of strategic sourcing of lower-risk starting materials, the efforts had little effect on serum-free…
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Vaccine Development and Production Challenges Manufacturers
Last year, CBER also approved expanded indications for Merck’s Gardasil 9 vaccine based on studies showing effectiveness against a wider set of human papilloma virus. A Merck scientist similarly expla…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
The cost of the virus-retaining filter, which can approach that of the protein A resin, can be reduced by using prefilters or optimizing protein concentration, temperature, buffer composition, and sol…
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Bioprocess filter selection guide
Use this guide to quickly select the right filters for depth filtration, tangential flow filtration, sterile filtration, or virus filtration. The filters are available in a range of formats and scales…
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Report from the 6th International HTPD Conference
Another presentation during the modeling session that gained interest was Lukas Döring from Rentschler, who talked about the possibilities to use mechanistic modeling for virus clearance studies. Inde…
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Report from the 12th Plasma Product Biotechnology Forum
…ext generation Fc receptor–targeting biologics for treatment of autoimmune diseases, and one from ViruSure on next generation sequencing as a powerful tool for adventitious virus testing.
U…