Search results for " optimization" in Articles / App Notes
Article
Development of column packing methods based on pressure flow measurements
This paper provides a brief overview on the pressure-flow relationship for chromatography resins in packed and compressed beds, and the optimization of a suitable degree of bed compression when develo…
Article
Modeling Bioreactor Performance
Modeling is used to gain insight into not only bioreactor performance, but to evaluate the economics and operational excellence of bioprocesses, as well as for process optimization (scale-up, scale-do…
Article
High-Throughput Process Development Handbook
Time-to-clinic and time-to-market are two key factors for successful biopharmaceutical development. Efficient development of the manufacturing process is a crucial component of the overall project…
Article
Downstream Processing Continues to Worry CMOs
CMOs are working hard to improve performance by investigating new technologies for filtration and purification.
By Eric S. Langer
Downstream processing continues to be a significant pain poi…
Article
Generating a Fully Processed Antibody
The authors outline cell-line development and process scale-up for an antibody program in which the antibody requires additional processing by a site-specific enzyme for correct functionality.
B…
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Managing Biomanufacturing Capacity Expectations
Capacity for complex therapeutics is becoming increasingly difficult to predict.
By Randi Hernandez
Demand for any given new product is typically only known after significant investments h…
Article
Continuous Processing for the Production of Biopharmaceuticals
While improvisation at each step is important, future research needs to focus on integration of the multiple unit operations into a single process and optimization of the entire bioprocessing train as…
Article
Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process.
By Marcos Simon, Juan J. Giner-Casares
Cell…
Article
Innovative Therapies Require Modern Manufacturing Systems
FDA and industry see progress and challenges in bringing cutting-edge medicines to patients.
By Jill Wechsler
FDA set a 19-year record in 2015 in approving more new drugs and biologics, and …
Article
Antibody Production in Microbial Hosts
Many advances such as translation region initiation (TIR) optimization, engineering of secretion pathways, and co-expression of molecular chaperones have been made for enhancing antibody productivity …