Search results for " modeling" in Articles / App Notes
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Newer classes of biotherapies will require innovations in processing technology.
By Glen R. Bolton, Bernard N. Violand, Richard S. Wright, Shujun Sun, Khurram M. Sunasara, Kathleen Watson, Johna…
Article
In silico optimization of AAV full/empty particle separation with AIEX
Mechanistic modeling is the tool of choice to find the optimal AIEX chromatography method.
We present a guiding workflow showcasing in silico process optimization of full and empty AAV5 particle se…
Article
Top Tips for Successful Development of Antibody Chromatography Processes
And to really increase your learning, you can also work with mechanistic modeling. In a mathematical way, this describes how different components or different substances behave inside the column. This…
Article
HTPD 2023 conference is coming up. What will be discussed and what happened last time?
The sessions guided by Cytiva modeling specialists will cover an introduction to the topic, benefits, and basic workflows of in silico process development and a deep dive into case studies and further…
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Digitalized PD: Speeding up downstream process development
Mechanistic models enable the simulation of chromatography processes based on fundamental natural laws, such as fluid dynamics and thermodynamics. In silico simulations of chromatography proce…
Article
Top Process Development Trends for 2022 and a Look into 2023
Mechanistic modeling is a mathematical representation of the physiochemical transport and interactions that occur during chromatography, and can be applied for mAbs process development, but also advan…
Article
Simulating chromatography processes in the growing molecular diversity
Mechanistic modeling can play a key role in overcoming these challenges as they are not limited to a certain class of biomolecules but are broadly applicable. Depending on the specific molecule and th…
Article
Tools and methodologies for smarter downstream process development
…ing downstream methodologies and tools to make PD faster and smarter?
Considering mechanistic modeling as an emerging technology, where do we stand today with mechanistic modeling?
Learn…
Article
Accelerating VLP purification process development
See how using mechanistic modeling can speed up the purification process development of virus-like particles (VLPs).
Indeed, a method for the large-scale production of VLPs is produ…
Article
Updating Viral Clearance for New Biologic Modalities
Viral clearance processes and guidance must evolve along with newer biotherapeutic modalities.
By Feliza Mirasol
Ensuring viral clearance (i.e., removal) in downstream purification has becom…