Search results for " cell"
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
…hallenges
- Validation challenges
- Need for greater process control
- Cell line stability problems
- Ability to scale-up process.
Interestingly, whi…
Article
The Need for Advanced Process Modeling for New Therapeutic Biologics
Early on, the process sequence and technologies can be changed, including cell lines and expression systems. By the time we are in production, however, these are fixed. Therefore, to fully optimize th…
Article
Upstream PD Time-Saver: Optimize Early
Click here to read the article >>
Optimization is key to achieving a high-producing CHO cell culture. Identify the right combination of culture medium, feed supplements, and feeding strategy …
Article
Driving Improved Access to Biosimilars
“In that case, they would have all the original cell lines. But another company developing a biosimilar would be using a different cell line, posing potential risk because of the inherent variability …
Article
Tips for Viral Vector Production
The viral vector market is highly active, and the interest in production technologies is driven by recent approvals in cell and gene therapy. In this blog article, insights are shared around the cha…
Article
Why, Why, Why…ELISA? A Look at the Benchmark HCP Assay
Click here to read the article >>
Biologics developers and manufacturers demand an accurate and reliable assay for host cell protein (HCP) quantitation. Let’s take a close look at why analytica…
Article
Nurturing Knowledge from Disparate Data Streams
Because biologic drug substances are produced in cells or microorganisms, their structures and compositions can vary slightly from batch to batch, leading to inherent variability, according to Tiffani…
Article
State of the Biopharmaceutical Industry: Lessons from 2018 Survey Data
For example, our studies have shown rather consistent incremental increases in upstream cell culture titers over the past three decades; and it took well over a decade for single-use equipment to atta…
Article
A Look into the Future of Biopharmaceutical Quality
…ue to advances in areas such as recombinant DNA and hybridoma technology, and more recently gene and cell therapies. As these advancements have occurred, new quality regulations have been developed t…
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Trends in adoption of diverse mammalian expression systems have also not materialized, as Chinese hamster ovary (CHO) cell lines have become the dominant expressions systems. In fact, nearly 80% of re…