Search results for " cell"
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News: Cytiva Adds ELISA Kit to End-to-End HCP Monitoring Capabilities
Cytiva is pleased to announce the new Amersham HCPQuant CHO kit, a generic for detecting host cell protein impurities in drug samples produced in CHO cell lines.
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Advances in Engineering of Protein-Based APIs
For instance, mouse cells that produce mAbs have been modified by knocking in human genes and knocking out mouse genes. Amgen’s XenoMouse technology has been used to produce the marketed mAb therapeut…
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Biopharmaceutical Process Development: 2018 Lessons and 2019 Predictions
Interest in Cutting-Edge Therapies Continues to Grow
With FDA’s first approvals of cell and gene therapies now more than a year old, activity in these areas shows no signs of slowing down. Proce…
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A Plastic Pipeline for Commercial Bioprocessing?
Quality and performance
“Clients sometimes have a predisposition to one manufacturer or another based on cell performance or other factors,” says Hughes. “We’ve been pretty successful in moving pr…
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Integrated Semi-Continuous Process for mAb Production
…s in the area of continuous processes typically deals with single unit operations, such as perfusion cell culture or continuous chromatography. Examples where two or more unit operations are connecte…
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Biopharma Seeks Balance
New paradigm: Gene and cell therapies
FDA’s approval of the first cell and gene therapies in 2017 created new dynamics in the biopharma industry as well as new science, technology, business, and e…
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Leveraging Data for Better Biopharmaceutical Process Control
…ess measurements, because precise levels of nutrients and oxygen must be monitored closely to ensure cell culture viability and the health of the process. For many years, though, extending this appro…
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Roadmap Leads to Innovative Biomanufacturing Strategies
…ngineering firm; and Bert Frohlich is an independent consultant who previously served as director of cell culture process development at Shire Pharmaceuticals.
Different perspectives
BioPharm:…
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Process Chromatography Selection for Downstream Processing Applications
…s has recently proven to be an alternative for improved filter capacity in the clarification of high cell density cultures, as well as a means of reducing some process impurities in the initial purif…
Poster
Residual DNA analysis in influenza vaccine processing
Samples from the vaccine purification process contain different buffers, salts, and host cell compounds, and varies 3–4 logs in DNA concentration from harvest to the final product, which all put strai…