Search results for " cell"
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Impurity ELISA automation for faster process development
Host cell proteins (HCPs) produced by cells during biologic manufacturing must be removed from the final product to protect patients. However, it’s challenging to detect HCP, and this step can…
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Establishing a Robust Workflow to Identify High-Performing GOCHO™ Clones
Our cell line development platform uses the GOCHO™ host cell line to minimize the risk and timeline to develop high-performing clones suitable for manufacturing.
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Current Techniques and Challenges Presented in Scaling Between Bioreactors
However, different cell lines may differ significantly in their oxygen requirement and behavior in the bioreactor. By doing the math upfront and taking all available data into consideration it will si…
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Enhancing Resins Addresses Purification Concerns
Now, we start to see a new landscape based on a variety of new modalities such as viral vectors, mRNA, pDNA, cell and gene therapy, and oligos,” he adds.
Ihre notes that a common feature of …
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Scalable AAV Production Process for Gene Therapy
Several viruses have been investigated for use in cell and gene therapy; adeno-associated virus (AAV) has emerged as the main vector for gene therapies. Here, we describe how we developed an efficient…
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Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
“With this partnership, Akron demonstrates its continued commitment to supporting the advancement of cell and gene therapies with cGMP [current good manufacturing practice]-compliant solutions at indu…
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Lentiviral Vector Upstream Process in Single-use Bioreactors
These properties make them well-suited for in-vivo and ex-vivo gene and cell therapies. However, cost-effective manufacturing of lentiviral vectors at commercial scales has proven difficult and remain…
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Good Manufacturing Practices: Challenges with Compliance
Cohen (Lubrizol): There are various regulations and guidelines around the world regarding the manufacture of biologics, which include information about control of feedlots and cell lines. These addres…
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Scalable ADCF Virus Production Using HyClone™ VaccineXpress Medium
Small-scale microcarrier cultures were optimized using spinner flasks by closely monitoring cell growth, viability, and morphology. The results were used for scaling up the process to a ReadyToProcess…
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2019’s Top Bioprocessing Trends and What to Expect in 2020
FDA approvals announced during the year for cell and gene therapies prompted the need to consider manufacturing facility designs specific to cell and gene therapy workflows, as well as the need to exp…