Search results for "CIP" in Articles / App Notes
Article
Evaluating Surface Cleanliness Using a Risk-Based Approach
For automated clean-out-of-place (COP) and clean-in-place (CIP) applications, it is important to review coverage and flow velocity in vessels and piping, drainability of the wash and rinse solutions, …
Article
Hybrid Bioprocessing: A Q&A with Andrew Sinclair
Removing clean-in-place (CIP) and sanitization-in-place (SIP) from the equipment are primary drivers for simplification, the reduction in size in vessels so that everything fits into single floor faci…
Article
Re-use of Protein A Resin: Fouling and Economics
While the base matrices and ligand densities for the MabSelect and MabSelect SuRe are identical, the latter provides greater stability under alkaline conditions used in clean-in-place (CIP) protocols.…
Article
Automating Bioprocesses
One of the most significant differences is that SUS do not require the clean-in-place (CIP) and sterilize-in-place (SIP) systems employed in stainless-steel equipment systems, which saves initial capi…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
In addition, Protein A resins with the ability to withstand repeated cleaning-in-place (CIP) with low-cost sodium hydroxide (NaOH) considerably improves process economics.
Protein A Resins …
Article
Alkaline stability of Fc and VH3 binding in protein A resins
In this study, we have looked at how different antibody binding sites of a protein A ligand are affected by cleaning in place (CIP). We evaluated NaOH incubation and the effect of performed CIP cycles…
Article
Strategizing for Rapid Changeovers in Biologics Manufacturing
Other important facility design aspects for rapid changeover, according to Machulski, include: quality by design, design for manufacturability principles (i.e., lean, single-minute exchange of dies [S…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
These technologies provide several advantages over stainless-steel systems, including reduced capital investment, elimination of cleaning in place (CIP), and cleaning validation. These advantages, acc…
Article
Efficient Sodium Hydroxide Sanitization with a Novel Procedure of AxiChrom™ Columns Packed with Chromatography Resin
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Sodium hydroxide (NaOH) cleaning-in-place is the widely accepted method of sanitization employed by biopharmaceutical manufacturers to avoid the excessive costs and delays of a…
Article
Development and Future of Protein A Chromatography Technology: Q&A with Jonathan Royce, Business Leader Chromatography Resins, Cytiva
This week Process Development Forum talks about Protein A with Jonathan Royce, business leader for Cytiva chromatography resins.
mAb purification platforms are very well established, and …