Search results for " DNA"
Article
A scalable single-use two-step plasmid purification process
While MAb processes have become much more efficient, production of mRNA and viral vectors is still hindered by the requirement for a reliable source of high-quality plasmid DNA (pDNA), which typically…
Article
Manufacturing mRNA for research and beyond
This eBook guides you in the practical aspects of setting up an mRNA research laboratory. Get insights on methods, materials, and workflows for mRNA synthesis and scale up.
Explore the mRNA…
Article
Need solutions for large-scale production of mRNA-based molecules?
Therapies based on messenger RNA, such as mRNA vaccines, have revolutionary potential. mRNA therapeutics offer precise and individualized therapy and avoid manufacturing issues associated wit…
Article
New to mRNA manufacturing? Here's what you need to know
Click above for an in-depth guide on mRNA manufacturing.
Multimedia
Q&A: Oligonucleotide synthesis in process development and scale-up
In this video, Greg Farlow, RNA/DNA synthesis product specialist at Cytiva, talks about the typical challenges with oligonucleotide synthesis in process development and key considerations when scaling…
Article
Q&A: Oligonucleotide synthesis in process development and scale-up
Farlow
In this video, Greg Farlow, RNA/DNA synthesis product specialist at Cytiva, talks about the typical challenges with oligonucleotide synthesis in process development and key cons…
Article
Top Process Development Trends for 2021 and a Look into 2022
They are further categorized into gene and cell therapies that use vectors such as AAVs, adenoviruses, and lentiviruses for delivery; oligo-based therapeutics such as anti-sense DNA, siRNA, mRNA, spli…
Article
Single-Use Technologies Prove Effective for Viral Vector Process Development
The presence of serum, culture harvest viability, turbidity, cell lysis reagents, contaminant DNA levels, and residual transfection agents are all upstream factors. Overall process scalability and rob…
Article
The Importance of Process Intensification and PAT for Achieving Real-Time Release
Thus, for glycoform, host-cell protein and DNA, protein aggregation/fragmentation, endotoxin, and many other analyses that rely on an array of off-line separation and detection technologies, there are…
Article
Updating Viral Clearance for New Biologic Modalities
Generally, viral clearance methods for these processes remove known impurities, such as DNA and HCP, by using assays that were developed and evaluated for a specific cell line, says Berrie. Thus, for …