Search results for " bacteria" in Articles / App Notes
Article
Antibody Production in Microbial Hosts
Further, mAb production in microbial hosts such as bacterial cells completely abrogates the nuisance of glycosylation control and speeds up production timelines, further simplifying bioprocessing. The…
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Fermentation for the Future
Typical examples include the prokaryotic bacteria Escherichia coli (E. coli) and the eukaryotic yeasts Saccharomyces cerevisiae, Hansenula polymorpha, and Pichia pastoris (P. pastoris). Recombinant te…
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Selecting a Comprehensive Bioburden Reduction Plan
Filtration
BioPharm: How do endemic bacteria affect the type of filter needed for filtration?
Mittelman and Anicetti (PDA task force): While bacteria (and fungi) may be present in all in-proce…
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Ensuring Viral Safety of Viral Vaccines and Vectors
UV-C irradiation has been used in the food, plasma, and biotech industries (for packaging and surface sterilization) and is effective against various biological contaminants, including bacteria and vi…
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Ensuring the Biological Integrity of Raw Materials
Those include bacteria, yeast, molds, viruses, and sometimes prions.
Mycoplasmas are the smallest of free-living organisms, and are frequent contaminants of mammalian cell cultures. They can alter…
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Single-Domain Antibodies for Brain Targeting
Firstly, sdAbs are antibody-derived fragments that can be expressed in bacteria as active, soluble, and robust proteins. Additionally, single variable domains are known to be able to potentially targe…
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Advances in Sterilization Technologies for Overcoming Viral-Vector Manufacturing Challenges
Sterile filtration will remain the standard, but with more automation
The fundamental issue with sterile viral-vector manufacturing is the need to keep out or remove undesired organisms such as bac…
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Virus-like Particles as Therapeutic Moieties of the Future
At least 110 VLPs have been constructed so far from 30 different virus families (1), and a variety of expression systems ranging from bacteria to mammalian cell systems have been used for their produc…
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Can Vaccine Development Be Safely Accelerated?
The plasmids are then produced in large quantities using bacteria. The overall development and approval timeline is thereby significantly reduced.
Inovio began animal testing of INO-4800, its C…
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Leveraging Data for Better Biopharmaceutical Process Control
Leveraging Data for Better Biopharmaceutical Process Control
The need to improve and understand processes is moving PAT and more advanced control strategies beyond the lab into manufacturing and dow…