Search results for " bacteria"
Article
Platform Technologies Improve Protein Expression
coli ] bacteria), but with the addition of engineered versions that may overcome the drawbacks of earlier non-engineered versions of these platforms. “I have to say, however, that the possibility to s…
Poster
Collaborating to address the bioburden challenge
Bacteria and their byproducts can negatively affect the safety and potency of a biopharmaceutical drug. At a minimum, bioburden contaminations lead to reduced productivity as a result of lost batche…
Article
Real Time Continuous Microbiological Monitoring
…e detection cell, resulting in the real-time detection of both inert particles and biologics such as bacteria, yeasts, and molds. Fluorescent (or fluorophore) dyes (molecules) can absorb light at one…
Article
Implications of Cell Culture Conditions on Protein Glycosylation
Certain bacteria can be used for production of the simplest proteins, those that are composed only of amino-acid polymers, with no post-translational modifications (PTMs) such as glycosylation, becaus…
Article
Aseptic Processing: Keeping it Safe
Filters, in particular, should be analyzed for removal of bacteria (such as challenge organism Brevundimonas diminuta) from the stream per ASTM 838-05, and investigators should be able to demonstrate …
Article
Bioprocessing Advances in Vaccine Manufacture
Advances in techniques and single-use systems are revolutionizing vaccine manufacturing.
The vaccine industry, particularly, in major Western markets, continues to be dominated by a few majo…
Article
Elucidating Biosimilars Characterization
Biological molecules are also manufactured by processes involving living organisms, such as genetically engineered bacteria, yeast, or mammalian cells, and although these processes can be well-defined…
Article
A Look Ahead at BioPharma Manufacturing and Regulation
Among these species are common water bacteria that CDC [Centers for Disease Control and Prevention] have shown to be difficult to detect using compendial methods. In collaboration with CDC and with he…