Search results for " purification"
Poster
Purification platform challenges and strategies for handling of "tricky" MAbs
In the work presented here, capture using high-capacity protein A medium (resin) was followed by polishing using a novel cation exchange chromatography medium.
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A Closer Look at Affinity Ligands
Breaking down affinity ligands
BioPharm: What are affinity ligands and how do they contribute to the downstream purification process?
Bekker (BioCina): Affinity ligands are molecules that can bi…
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A Look at the Affinity Chromatography Landscape
With the advent of next-generation biopharmaceuticals, chromatography material suppliers have been challenged to develop affinity ligands and support systems that enable the separation and purificatio…
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Addressing the Challenges in Downstream Processing Today and Tomorrow
The standardization of cellular expression systems, bioreactor conditions, purification processes, manufacturing hardware, and disposables has resulted in faster clinical development and lower costs. …
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Process Chromatography: Continuous Optimization
“Different ion exchange chemistries can offer unique selectivity depending on the purification needs, so a variety of chemistries are tested based on the application,” Parra says.
Affinity resins …
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Trends in Downstream Bioprocessing
It involves the removal of insoluble cell debris and particulates; product isolation through extraction, adsorption, ultrafiltration, or precipitation; product purification through affinity chromatogr…
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Overview of a scale-up of a cell-based influenza virus production process using ReadyToProcess equipment
Downstream Processing and Purity Analysis
For downstream laboratory-scale purification, performed using standard, non-disposable equipment, approximately 10 L virus harvest from the upstream proce…
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Innovative Chromatography Resins Can Improve Purity and Quality
Recent advances in chromatography resins can effectively impact the purification unit operation with positive consequences that reverberate both upstream to the bioreactor and downstream to filtration…
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Technology Innovations Improve Process Chromatography Performance
Recent developments in process chromatography have addressed challenges in downstream separation and purification and led to improved bioprocessing.
Current challenges
The biopharmaceutical ind…
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Gene Therapies Push Viral Vector Production
Learning how process parameters in the upstream process influence the purification process is fundamental for a good quality-by-design strategy. Furthermore, it will be interesting to see the developm…