Search results for " titers"

Poster A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
• The increased upstream titers in mAb production seen in recent years may make the Protein A capture step a bottleneck.  • Protein A columns columns are also more prone to bioburden contamination…

Article Process Chromatography: Continuous Optimization
“An increase in binding capacity will be beneficial for process economy reasons when purifying steadily increasing upstream titers,” he states. Current protein A resins are also exposed to feeds with …

Article Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists. By Randi Hernandez When human cells travel throug…

Article Being Thorough When Transferring Technology
Communication and taking the time to develop the process are key to successful transfer and scale up of biologics. By Susan Haigney Editor's note: The following is an extended version of the…

Article Speed and Flexibility Are Dual Goals for Biopharma Operations
…ions—such as advances in bioreactor technology, media, buffers, and cell lines that produce higher titers in smaller systems—reflected an evolution in technology. Other product introductions included…

Article Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
By Catherine Shaffer Four biosimilars have been approved for the market by FDA as of February 2017, and more are in the pipeline. Now that biosimilars are here to stay, manufacturers are devel…

Poster Validation of Cytodex™ Gamma microcarrier-based virus production in single-use bioreactor systems
A majority of cell lines commonly used for viral vaccine production are anchorage-dependent and require expansion on solid surfaces. Here, we describe different approaches for the cultivation of Ver…

Article Process Chromatography Selection for Downstream Processing Applications
Improvements in upstream processing have increased titers, shifting bottlenecks downstream from being a volumetric issue to where it is mainly the binding capacity of the resin that is limiting. T…

Article Perfusion in the 21st Century
Dramatic increases in the titers achievable with fed-batch culture, which reached levels as high as 4.7g/L (3), eventually eliminated the need to pursue continuous processing for increased productivit…

Article Downstream Processing Continues to Worry CMOs
Downstream continues to fail to keep up with the recent advances in upstream yield and titers. Reference 1. BioPlan Associates, 13th Annual Report and Survey of Biopharmaceutical Manufacturi…

Previous PageNext Page