Search results for " biopharmaceutical"
Article
Preparing for the Future: Visions and Insights for Biomanufacturing
The biopharmaceutical industry has a reputation of being averse to change. Yet, new market dynamics, such as growing competition from biosimilars and niche drugs targeting smaller patient populations,…
Article
Sensitive and Reproducible SPR-Based Concentration and Ligand-Binding Analyses
Surface plasmon resonance (SPR) assays are used across the life cycle of a biopharmaceutical, from target identification, through CQA determination, development, and on-going quality control. This art…
Article
Integrated Semi-Continuous Process for mAb Production
A complete process for the production of a biopharmaceutical consists of a great number of distinct unit operations, for example, cell culture, filtration, and chromatography. Linking these differen…
Article
Challenges in Cell Harvesting Prompt Enhancements
The past decade has seen the biopharmaceutical industry move toward significantly higher titers, and, as a result, higher cell densities. Biomanufacturers have been shifting from large stainless-steel…
Article
Biopharma Says It Has an Evolution in New Technologies and Processes
However, most product introductions focused on enhancements to existing product lines or technologies to improve current biopharmaceutical manufacturing processes. A recurring theme was the need for n…
Article
Making the Move to Continuous Chromatography
…roducing different process intensification initiatives, there is still, to my knowledge, no approved biopharmaceutical product with a continuous chromatography step, and some aspects/questions in the…
Article
Modern Manufacturing Key to More Effective Vaccines
He said these developments will “transform the biopharmaceutical industry” by boosting local production and supply of high-quality vaccines in developing countries, while also expanding capacity for r…
Article
Modeling and Miniaturization: Key Topics at Successful HTPD Conference
Since then, HTPD in chromatography applications has been well established among most biopharmaceutical companies, but has also expanded to upstream and cell culture screening as well as to formulation…
Article
How to Address Bioburden Challenges: Insights and Tips
Bioburden control is an area of serious concern for anyone making mAbs or other biologicals. Manufacturers’ efforts to avoid microbial contamination are today being complemented by developments from…
Article
Process Chromatography: Continuous Optimization
Monoclonal antibodies (mAbs), which today account for approximately 50% of the total revenues of all biopharmaceuticals according to David Westman, global product marketing manager for Cytiva, are typ…