Search results for " conjugate"
Article
Designing a Biomanufacturing Facility Incorporating Single-Use Technologies
Will the facility be manufacturing monoclonal antibodies, recombinant proteins, vaccines, antibody-drug conjugates, or fragment antibodies? Also, will the products be mammalian cell-derived or microbi…
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mAbs to Watch in 2016
Inotuzumab ozogamicin—Pfizer’s drug candidate for the treatment of acute lymphoblastic leukemia (ALL) is the only antibody-drug conjugate on the potential approval list for 2016. The drug received a B…
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Best Practices in Qualification of Single-Use Systems
Ducry, Antibody-Drug Conjugates (Humana Press, 2013).
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Aseptic Processing: Keeping it Safe
Many newer facilities, such as SAFC’s new antibody-drug conjugate-focused floor in its St. Louis, MO campus, have spaces that are designed to handle media fill for various types of products and have i…
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Host-Cell Protein Measurement and Control
Then, detection antibodies, conjugated directly with an enzyme or through a biotin-avidin magnification, bind to the captured HCPs. An enzyme, commonly horseradish peroxidase (HRP), can catalyze the s…
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High-Throughput Process Development in an Historical Environment
The value of HTPD methodology was helpful, with different aluminum salts and different types of vaccines (virus-like particles, polysaccharide conjugates, and proteins) evaluated.
Winning an Oly…
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Pharma Investments Reflect Key Industry Trends
Shrinking facility size, growth of biologics, and emerging market demand influence pharma investments.
Aug 2, 2014
By: Cynthia Challener, PhD
Pharmaceutical Technology
Volume 37, Iss…
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Analyzing Proteins Using SEC, MALS, and UHPLC
Some also notes that for proteins conjugated to a modifier such as glucose, polyethylene glycol (PEG), or surfactant micelles for which no standard SEC reference molecules exist, the combination of MA…
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Trends in BioPharma Approvals in 2013
This drug is Herceptin to which a small cytotoxic molecule (DM1) has been conjugated, and like Herceptin, it is approved for the treatment of HER2-positive metastatic breast cancer. As in the case of …
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HT Multi-Product Liquid Chromatography for Characterization of Monoclonal Antibodies
HPCE methods for the identification and quantitation of antibodies, their conjugates and complexes. J Pharm Biomed Anal. 1997;16:377–93.
19. Hunt G, Nashabeh W. Capillary electrophoresis sodium do…