Search results for " industry"
Poster
Benchmarking, scalability, and protein production in CHO cell culture
The most widely used cell lines in the bioprocess industry originate from CHO cells. With the large number of CHO clones in use, it is important to have a cell culture medium that supports high via…
Article
Selecting a Comprehensive Bioburden Reduction Plan
Despite normal flow filtration being an established operation within the industry, we continue to see some relatively poor practices being performed. Confusion remains amongst bioproducers who believe…
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
By Anna Grönberg
An important area of focus for the biopharma industry is the elucidation and development of robust, efficient, and economic purification strategies for new monoclonal antibodies (…
Article
Cleaning of Dedicated Equipment: Why Validation is Needed
Design and technical aspects of equipment are covered by good engineering practices (6) and some technical references; practical guidelines for equipment design are also provided by food industry regu…
Article
Using Single-Use Technologies in Downstream Processing
While the industry has used SUS in upstream processing for some time now, the use of single-use technologies is becoming popular in downstream processes as well. And it appears that the single-use tre…
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Taking a “Development-by-Design” Approach to Cell Therapies
There is a tendency for people in the industry to ignore the product profile until they have all the answers, says Hampson. “Instead, it needs to be developed really early, even when you don’t have al…
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Optimization of Protein Expression in Escherichia Coli
The BL21(DE3) strain is one of the most commonly used strains in both industry and academia. It carries the phage T7 gene 1—encoding T7 RNA polymerase—in its chromosome under the control of the lacUV5…
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Vaccine Development and Production Challenges Manufacturers
NIH is collaborating with industry and leading scientists in Liberia to launch a large Phase II/III trial of two leading vaccine candidates from GSK and Merck with NewLink Genetics, explained Anthony …
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The Bullish Outlook for Biosimilars
The cost of drugs has become a focal point of popular and industry dissatisfaction in the US, in spite of the relatively modest percentage of overall healthcare costs accounted for by pharmaceuticals …
Article
Fermentation for the Future
Both academic and industry researchers are working to overcome these issues and have made notable advances in the development of engineered yeast strains.
Much of the work was accomplished in P. p…