Search results for " upstream" in Articles / App Notes
Article
Safety Drives Innovation in Animal-Component-Free Cell-Culture Media Technology
However, the reality is that the routine methods used for virus removal and inactivation have not always been sufficient to eliminate all of the upstream process risks presented by viruses. Viral cont…
Article
CMOs Continue to Improve Overall Biomanufacturing Performance
Separately, 43% of industry respondents reported outsourcing at least some upstream process development activities to some degree, up from just 17.1% back in 2010. Additionally, 41% reported at least …
Article
Evaluating the Use of Continuous Chromatography
Although significant strides have been made to advance continuous upstream processing, downstream processing has not advanced at the same pace. However, according to Gerstweiler et al., “Research on c…
Article
Insights and Strategies for Successful Development of Scalable AAV Processes: Part 2 of 2
Topics covered include:
1:00 – The upstream approach for AAV production, such as finding the balance between different parameters in the design of experiments to create a robust production proc…
Article
Cell-free Expression Systems Pose Cell Culture Alternative
Feliza Mirasol
Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product of cell culture. One approach that potentially offers the benefit of a “cleaner”…
Article
Leveraging Data for Better Biopharmaceutical Process Control
Are more biomanufacturers adopting PAT and advanced control in biopharma?
Menezes:The initial use of PAT in bioprocessing was focused on monitoring specific culture attributes in upstream proce…
Article
Tools for Continuous Bioprocessing Development
The industry needs technologies that can enable upstream processes to move quickly and seamlessly between partners, whether internal or external. Currently, cultural challenges and established ways of…
Article
Explore the Process Intensifier App
• Both as a connected operation: what happens when you combine upstream and downstream approaches?
Article
Top Challenges to Overcome When Developing AAV Processes: Part 1 of 2
Topics covered include:
1:00 – Two main challenges for upstream AAV process development, including which development platform to use and scalability
3:09 – Parameters evaluated for AAV p…
Article
Setting Up Bioprocessing Systems for Digital Transformation
As John Liddell, chief technologist, Biologics, at CPI indicates, mAb processes can generate significant amounts of data because, in upstream processing, cell culture processes typically run for 14 da…