Search results for " upstream" in Articles / App Notes
Article
Outsourcing Trends in Biopharmaceutical Manufacturing
Similarly, the proportion of respondents reporting having outsourced upstream process development has more than doubled since 2010, from 17.1% to 43.2%. Comparable rates of growth are also seen with o…
Article
Best Practices in Adopting Single-Use Systems
Single-use technologies have evolved from a supporting role for upstream operations (e.g., media storage and cell harvest) to near-complete platform processes that include all downstream processing st…
Article
Comparing Protein A Resins for Monoclonal Antibody Purification
The increase in upstream productivity creates a subsequent demand on downstream processing to address high-titer HCCF.
Commercial-scale purification of mAbs usually contains two or three chroma…
Article
PDA's Technical Report for Biotech Cleaning Validation
For these reasons, limits for the manufacture of bulk actives in biotech are generally established based on industry standard practice of about 5–10 ppm TOC for upstream processes and 1–2 ppm for down…
Article
Addressing the Challenges in Downstream Processing Today and Tomorrow
Increasing upstream titers and shrinking development timelines have posed several challenges to downstream process development of mAbs. Some of the major strategies and tools to address these challeng…