Search results for " resin" in Articles / App Notes
Article
Accelerated flavivirus vaccine production with modern tools and solutions
For downstream processing, modern chromatography resins offer high selectivity and excellent pressure-flow properties for high productivity inmanufacturing-scale purifications. This white paper includ…
Article
Evaluating E&L Studies for Single-Use Systems
Extractables studies on the chromatographic resins were already available from the vendors so all resins involved in the purification process were disconnected and excluded from the extraction study, …
Article
High-Throughput Process Development Handbook
Time-to-clinic and time-to-market are two key factors for successful biopharmaceutical development. Efficient development of the manufacturing process is a crucial component of the overall project…
Article
Technology solutions simplifying chromatography unit operations
Chromatography operations typically involve steps such as resin slurry preparation, column packing, cleaning, unpacking, and resin storage. While each of the aforementioned steps can potentially be …
Article
Downstream Processing Continues to Worry CMOs
A majority of CMOs are considering:
• Use of high capacity resins
• In-line buffer dilution systems
• Single-use disposable tangential flow filtration (TFF) membranes
• Single use-prep…
Article
ReadyToProcess™ Prepacked Columns
As a supplier of both the chromatography resin and the prepacked column, GE takes responsibility for the complete supply chain.
Watch video.
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
A similar approach was proposed for chromatography resins in another, separate study, but employed different methods (22). As mentioned previously, compendial microbiological tests were not included i…
Article
Selecting the Right Viral Clearance Technology
“Column chromatography will frequently be effective for virus reduction, but the degree of reduction is dependent on the resin type (mode of action), the conditions used for the separation, and the ch…
Article
Securing the Single-Use Supply Chain
“Doing so is not as easy as it seems due to supply chain complexity down to the resin suppliers and the varying approaches that can be taken. It really starts with a close interaction with SUS integra…
Article
Challenges of Protein Aggregation During Purification
At the same time, strong hydrophobic interactions between the resin and the product may lead to aggregate formation, according to Vedantham, again due to surface-induced structural perturbation of the…