Search results for "scale-up" in Articles / App Notes
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
This article highlights 15 years of changes in biopharmaceutical manufacturing.
By Ronald A. Rader, Eric La…
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Biopharma Says It Has an Evolution in New Technologies and Processes
A recurring theme was the need for new technologies to accelerate bioprocessing operations and to smooth scale-up from development to GMP processing.
Exhibitors announced new chromatography system…
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Modern Manufacturing Key to More Effective Vaccines
Vaccine development may be even more challenging, she observed, due to limited platform technologies for these products, potential for process change during technology transfer, scale-up difficulties,…
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Industry Adoption of Single-Use Systems Remains Low
Under their agreement, Sartorius Stedim will equip Abzena’s San Diego process development lab with industry technologies that enable fast scale-up to 500 L initially and later to the 2000-L scale sing…
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Techniques for Improving Process Development for Exosome-Derived Therapeutics
Ultracentrifugation is, however, quite difficult to operate and scale-up. Other isolation approaches such as chromatography haven’t been as successful historically because of the surface heterogeneity…
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Process Development: What May Lie Ahead in 2018?
Single-Use in Full Force
Single-use technology continued to advance from scale-up and clinical applications to clinical manufacturing and the top-10 most popular articles on the Process Developmen…
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Transformative Medicines Challenge FDA and Manufacturers
And process scale-up further requires identification and qualification of thresholds and specifications.
Combos crucial
The process of developing and delivering cutting-edge gene therapies a…
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Development of Purification for Challenging Fc-Fusion Proteins
Development of Purification for Challenging Fc-Fusion Proteins
This study outlines methods for an alternative protein-polishing process for challenging proteins.
…
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Process Chromatography: Continuous Optimization
Ion exchange resins that offer high capacities at high linear flow rates help to scale-up processes for the economic production of large-volume mAb drugs, says Bulpin. “The base beads of these materia…
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
Alternatively, upstream process scale-up can make use of perfusion reactors, which use a constant supply of cell-culture media while removing unwanted byproducts throughout a prolonged production run …