Search results for "scale-up" in Articles / App Notes
Article
Assessing Manufacturing Process Robustness
In manufacturing, this relates to attributes attributes of material, formulation, and associated processing parameters including scale-up factors, processing equipment, test method, personnel, and fac…
Article
Innovative Chromatography Resins Can Improve Purity and Quality
“Subsequent resin scale-up is then taken on by a preferred Navigo manufacturing partner, such as Repligen, who provides large-scale custom affinity resins for clinical/commercial GMP purification.”
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Article
Remote Monitoring and Big Data Advance Upstream Automation
“Increasing the production volumes of these processes will require scale-out rather than scale-up, which changes the nature of manufacturing bottlenecks. Implementation of full platform solutions will…
Article
Process Development: 2020 Reflections and 2021 Possibilities
Scaling up viral vector and virus manufacturing processes prompts the need for discussion on general guidelines for how to go about the scale-up process, which was of particular interest to Bioprocess…
Article
Akron Bio Will Install a Cytiva FlexFactory to Manufacture Plasmid DNA
Materials for cell and gene therapy manufacturing, such as pDNA, have been experiencing capacity constraints, and the platform will enable rapid scale-up to address supply chain bottlenecks.
“With…
Article
Testa Challenge 2020 Attracts Leading International Bioprocessing Innovators
Held over an intensive week in the Testa Center located at Cytiva´s Uppsala site, a unique biomanufacturing scale-up facility, the Testa Challenge aims to allow start-ups, research groups and companie…
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
… - Need for greater process control
- Cell line stability problems
- Ability to scale-up process.
Interestingly, while approximately 76% believe downstream continuous bi…
Article
Cytiva Expands Offering for ReadyToProcess™ Columns
ReadyToProcess columns are offered in seven inner diameters to meet the needs of upstream production. You can enjoy the flexibility of using our prepacked ReadyToProcess columns from benchtop to ful…
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Flexible Facilities for Viral Vector Manufacturing
When larger batches are needed, either scale-up or scale-out is used, depending on the type of process. Makowiecki explains that vector production using adherent cells in fixed-bed bioreactors is limi…
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Maximizing the Effectiveness of Upstream Bioprocessing Through the Combination of Lab Informatics and Instrumentation
With a scale-out rather than scale-up approach to meeting production requirements, there is a greater risk of variability in process conditions and product quality between individual bioreactors. Bior…