Search results for "scale-up"
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Report from the 12th Plasma Product Biotechnology Forum
The general trend was considered more interesting than specific values predicted, as scale-up and variability of analytical methods were not considered.
Another aspect of technical development …
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Current Techniques and Challenges Presented in Scaling Between Bioreactors
cell culture
In this video, Andreas Castan, Strategic Technology Partnerships Leader at Cytiva, discusses the current techniques and challenges in scaling between bioreactors.
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Scaling a mAb production process to Xcellerex bioreactors
Moving a monoclonal antibody production process from a microscale bioreactor to the Xcellerex XDR single-use platform.
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Approaches to scaling up Chromatography Processes
Scaling up chromatography resins requires a thorough understanding of their intended use.
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Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
And when it comes to PAT implementation, it will go through a lifecycle where it's developed in the laboratory, tested in a scale-up laboratory, and then eventually, it works its way into a larger com…
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Maximum Output Starts with Optimized Upstream Processing
“Modular and mobile solutions will be important for scale-up and capacity-expansion opportunities with much shorter lead times,” she observes.
SU technologies are also being widely implemented for…
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Scaling Up an E. coli Upstream Process for Plasmid DNA Production — from 2.5 to 160 L scale Fermenters
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This article summarizes the results of Escherichia coli growth performance for plasmid production in a 5 L glass fermentor, which was scaled up to 80 and 160 L scale in Xcellerex™ X…
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Assessing Manufacturing Process Robustness
In manufacturing, this relates to attributes attributes of material, formulation, and associated processing parameters including scale-up factors, processing equipment, test method, personnel, and fac…
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Innovative Chromatography Resins Can Improve Purity and Quality
“Subsequent resin scale-up is then taken on by a preferred Navigo manufacturing partner, such as Repligen, who provides large-scale custom affinity resins for clinical/commercial GMP purification.”
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Remote Monitoring and Big Data Advance Upstream Automation
“Increasing the production volumes of these processes will require scale-out rather than scale-up, which changes the nature of manufacturing bottlenecks. Implementation of full platform solutions will…