Search results for "scale-up"
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Cell-Culture Advances Test Bioreactor Performance Models
Traditional, reliable method
Typically, bench-top bioreactors are operated in the performance design space of larger bioreactors to model scale-up performance, according to Parrish M. Galliher, …
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Moving PAT from Concept to Reality
Furthermore, asserts Grieb, a well-characterized and monitored process together with scalable hardware can significantly reduce the cost and efforts of process scale-up and scale-down. Overall, theref…
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Development of column packing methods based on pressure flow measurements
…s, and the optimization of a suitable degree of bed compression when developing packing methods for scale-up.
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Modeling Bioreactor Performance
Modeling is used to gain insight into not only bioreactor performance, but to evaluate the economics and operational excellence of bioprocesses, as well as for process optimization (scale-up, scale-do…
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A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
The agency has accelerated approvals of breakthrough drugs, but identified the need for earlier scale-up chemistry, manufacturing, and controls (CMC) work. Equipment manufacturers displayed systems th…
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Biopharma Manufacturers Respond to Ebola Crisis
Tekmira’s antiviral utilizing lipid nanoparticle technology has been authorized for emergency use and is considering options for scale-up to produce some 900 doses by early 2015. And Sarepta Therapeut…
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PDA's Technical Report for Biotech Cleaning Validation
The performance of the cleaning process in the laboratory is then verified by conducting experiments in the pilot-plant or scale-up equipment. Adjustments to cleaning conditions may be made during the…
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Process development using a nonaffinity method vs Cytiva™ Protein Select™ resin
We also studied scale-up effects, and shared the results for runs performed onto a 10 cm bed height column.
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Explore ÄKTA pilot 600 in 3D
See how ÄKTA pilot™ 600 supports scale-up from process development to GMP clinical scale.
Explore this ÄKTA™ system in 3D
Article
Exosome isolation by tangential flow filtration and size exclusion chromatography
The workflows we describe are suitable for scale-up and combine tangential flow filtration (TFF) for the concentration of exosomes followed by gentle size exclusion chromatography (SEC) with our next-…