Search results for " bioprocess" in Articles / App Notes
Article
Improving PAT for Biologics
Implementing PAT for bioprocesses presents unique challenges given the greater complexity of cell-culture and fermentation processes, the variability of raw materials (particularly living organisms), …
Article
Continuous Processing for the Production of Biopharmaceuticals
While there is a plethora of emerging continuous bioprocessing technologies available in the market, there are almost no concrete examples of successful implementation and integration of a fully conti…
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Evaluating the Use of Continuous Chromatography
BioPharm: What is continuous chromatography, and how has it improved downstream bioprocessing?
Rozanas (Cytiva): Continuous chromatography differs from traditional ‘batch’ chromatography in two ke…
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Improving Upstream Predictability
“PAT has matured and is used more routinely now, through in-line pH, dissolved oxygen and carbon dioxide sensors, while use of Raman spectroscopy is increasing,” notes Darren Verlenden, head of biopro…
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The Need for Advanced Process Modeling for New Therapeutic Biologics
By Feliza Mirasol
Process modeling plays a crucial role in process development and in scaling up bioprocesses. As bioprocessing workflows increasingly shift toward automation, the approach t…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
Reduction in bioprocessing time is one advantage that single-use systems offer. As Young points out, reusable systems can typically require more than 12 hours from set-up to tear-down, while single-us…
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The New World of Biopharmaceutical Manufacturing
Over the past five years, these devices have steadily made progress in bioprocess operations as their scalability has increased.
Galliher (Cytiva): In the past five years, new advances in…
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Combining Microbioreactors and Advanced Statistical Techniques to Optimize a Platform Process for a New Host-Cell Line
By Colin Jaques, Daniela Lega
Over the past decade, two improved capabilities have changed the face of bioprocess design. First, the availability of high-throughput miniature bioreactors has made …
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Top Process Development Trends for 2021 and a Look into 2022
As we move into 2022, let’s take a look back at some of the most popular 2021 articles from the Bioprocess Development Forum.
Next-Generation Therapeutics: Improvements & Challenges
Advanced the…
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Tools and Processes for Mature and Emerging Therapies
In April 2019, at the INTERPHEX trade show in New York City, vendors of bioprocessing equipment and materials announced improvements to existing platforms, added options for upstream and downstream sy…