Search results for " bioprocess" in Articles / App Notes
Article
Under pressure: exploring root causes of leaks in single-use mixers
Equipment failures in large-scale bioprocess can be costly in terms of material loss and downtime. For large manufacturers, a batch failure (i.e., one that causes product loss) can cost millions of do…
Article
A Closer Look at Affinity Ligands
The most common example in the realm of bioprocessing is Protein A, which has an extremely high affinity for some immunoglobulin molecules. Other examples include antibody/antigen, enzyme/substrate, a…
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What is process development?
Learn more about process development
Get better understanding of definitions, activities, and things to consider when developing an upstream and downstream bioprocess
- Process developme…
Article
Enhancing Resins Addresses Purification Concerns
Christoph Burgstedt/Stock.Adobe.com
Enhancement of resin technology can improve the ability of chromatography to purify the growing landscape of increasingly complex biomolecu…
Article
Cell-free Expression Systems Pose Cell Culture Alternative
Feliza Mirasol
Among the challenges in upstream bioprocessing is the cellular waste generated as a by-product of cell culture. One approach that potentially offers the benefit of a “cleaner”…
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Common Challenges in Cross-Functional Process Development
Topic covered include:
1:28 – Common stumbling blocks in developing an effective bioprocessing operation
2:18 – Should upstream and downstream processes be developed concurrently or sepa…
Article
Basics in Process Development for Biotherapeutics
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Definitions, activities, and things to consider when developing an upstream or downstream bioprocess.
Article
Cell Culture Media Considerations and Optimization for Improved Titers and Protein Quality
Peggy Lio, Cytiva
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Peggy Lio, Senior Director of Global Cell Culture Services at Cytiva, explores the evolution of b…
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The Importance of Process Intensification and PAT for Achieving Real-Time Release
While these data lead to a better understanding of such bioprocesses and ultimately better process control, improvements and additional capabilities are still needed to achieve true in-line/on-line/at…
Article
Developing a Closed, Connected Single-Use mAb Purification Process
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Learn more on this case study to set up a closed and connected single-use monoclonal antibody (mAb) purification process that addresses a perfusion upstream process. In the Pr…