Search results for " bioprocess"
Article
Preclinical Evaluation of Product Related Impurities and Variants
This may be attributed to the complexities related to the use of cell lines, media formulation, and other bioprocessing steps that are prone to variability to varying degrees (4).
The inherent …
Article
Bioburden Entry Points in Downstream Processing
If you work in bioprocessing, you are no doubt aware of the need to prevent bioburden entry and proliferation, and reduce the complexity of the equipment and processes involved. Anastasia Lolas, for…
Poster
Rapid Process Development of a CIEX Step for a Biosimilar
A cation exchange (CIEX) chromatographic step was developed as part of a collaborative project, where expertise in the field of downstream purification and bioprocessing was combined with specific bio…
Article
Impact of Media Components on CQAs of Monoclonal Antibodies
…ot of interest for many years as a result of its critical impact on the animal cell technology based bioprocess development (3). Factors that play a role in media design originate from three major so…
Article
Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
Buffer preparation is both time-and space-consuming and can easily become a challenge in biomanufacturing. This application note describes a lean approach to buffer preparation by implementing in-li…
Article
Immediate, Flexible Capacity with Hydrated Buffers and Process Liquids
Historically, bioprocessing facilities have prepared buffers and process liquids in-house as a core activity. However, trends suggested buffer fluid preparation is one area seeing increase activity in…
Article
Sources of Bioburden You Might Have Missed
In this new blog-article, potential bioburden sources in bioprocessing are discussed and ways to address the risks.
Read more here
Article
Downstream Processing for Cell-Based Therapies
Rafiq, MEng, PhD, CEng, CSci, is associate professor of Cell & Gene Therapy Bioprocessing at the University College London, WC1E 6BT, UK.
Fernanda Masri is an account manager at Sartorius Sted…
Article
Single-use Bioreactors Have Reached the Big Time
Suppliers of single-use bioreactors continue to work closely with customers to address changing needs, such as those for next-generation cell- and gene-therapies and continuous bioprocessing.
“The…
Article
Reconciling Sensor Communication Gaps
Process analytical technology (PAT), quality by design, and individual company- or process-centric quality initiatives are driving the development of bioprocess sensors and probes. Single-use systems …