Search results for " Mabs" in Articles / App Notes
Article
Cleaning Protein A Resins with 1 M NaOH
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For more information, visit MabSelect Protein A resins
Article
Reducing Cross-Contamination Risks in Process Chromatography
Reducing Cross-Contamination Risks in Process Chromatography
Single-use systems provide replaceable fluid paths.
By Cynthia A. Challener
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Article
Downstream Processing for Cell-Based Therapies
As with the production of mAbs, significant research and development for CGT processes has focused on the intensification of upstream production. For example, several studies have investigated the opt…
Article
Single-use Bioreactors Have Reached the Big Time
The decision to use disposable bioreactors is now driven by commercial rather than technological considerations.
By Cynthia A. Challener
Single-use bioreactors available from various vendors…
Article
Walk Away and Do More Screening Preps
Developing a process or looking for a clone of interest often requires screening large numbers of samples. Many analyses require purified protein, and substantial hands-on time might be allocated to…
Article
Fed-batch supplements to boost cell culture performance
To increase the yield of a target protein, fed-batch culture is often employed in biomanufacturing processes. This application note demonstrates the enhanced performance of commonly used cell lines …
Article
Best Practices in Qualification of Single-Use Systems
The author discusses the current best practices in technical qualification of single-use systems.
By Weibing Ding, PhD
Single-use technology has been around for approximately two decades if …
Article
Use of Multivariate Data Analysis in Bioprocessing
Amanullah, mAbs, 2 (5), pp. 466-479 (September 2010).
2. A. S. Rathore and R. Mhatre, Eds., Quality by Design for Biopharmaceuticals (John Wiley & Sons, Hoboken, NJ, 2009).
3. A.S. Rathore, N.…
Article
Tackling Analytical Method Development for ADCs
“Traditional cysteine and lysine chemistry is still a significant part of the ADC regime, but we are seeing a greater breadth of linkers, toxins, mAbs, and classes of conjugation chemistry. New analyt…
Article
High-Throughput Process Development in an Historical Environment
Genentech is said to be working with less than 20 different formulations, developed mainly for mAbs, but these formulations have also been shown to work for other types of target molecules. Instead, t…