Search results for " Mabs"
Article
Recent Advances in the Use of Exoglycosidases to Improve Structural Profiling of N-glycans from Biologic Drugs
al, MAbs 9, 1349–1359 (2017).
15. S. Vainauskas, et. al, Sci. Rep. 8 (1), 9504 (2018).
16. T. Walsh, et. al, Bioinformatics online, DOI: 10.1093/bioinformatics/bty681, Aug. 7, 2018.
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Article
Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…
Article
Cleaning Protein A Resins with 1 M NaOH
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For more information, visit MabSelect Protein A resins
Article
Reducing Cross-Contamination Risks in Process Chromatography
Reducing Cross-Contamination Risks in Process Chromatography
Single-use systems provide replaceable fluid paths.
By Cynthia A. Challener
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Poster
Evaluation of Protein A resin lifetime during extensive use (overloading) in continuous chromatography mode
This application note compares the performance of MabSelect SuRe pcc resin designed for continuous capture of mAbs, with the conventional high-capacity Protein A resin MabSelect SuRe LX. The study was…
Article
Downstream Processing for Cell-Based Therapies
As with the production of mAbs, significant research and development for CGT processes has focused on the intensification of upstream production. For example, several studies have investigated the opt…
Article
Single-use Bioreactors Have Reached the Big Time
The decision to use disposable bioreactors is now driven by commercial rather than technological considerations.
By Cynthia A. Challener
Single-use bioreactors available from various vendors…
Article
Walk Away and Do More Screening Preps
Developing a process or looking for a clone of interest often requires screening large numbers of samples. Many analyses require purified protein, and substantial hands-on time might be allocated to…
Article
Fed-batch supplements to boost cell culture performance
To increase the yield of a target protein, fed-batch culture is often employed in biomanufacturing processes. This application note demonstrates the enhanced performance of commonly used cell lines …
Article
Best Practices in Qualification of Single-Use Systems
The author discusses the current best practices in technical qualification of single-use systems.
By Weibing Ding, PhD
Single-use technology has been around for approximately two decades if …