Search results for " Mabs"
Article
Report from the 6th International HTPD Conference
The QSAR model by Merck has been developed and trained with 10,000 data points from historical data on 40 proteins (mainly mAbs but a few Ab variants) and 51 resins. Calculated descriptors for protein…
Article
Fundamentals of hydrophobic interaction chromatography
…:
* recombinant proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Browse this HIC resour…
Article
Maximum Output Starts with Optimized Upstream Processing
This manufacturing is performed outside of mainstream biopharma, where most capacities and capabilities involve the production of mAbs,” he explains.
While Lange says that COVID-19 has created a t…
Article
A Continuous Confidence Boost
Continuous processing of monoclonal antibodies (mAb) could offer a number of advantages, but regulatory uncertainty and upfront investment remain sticking points.
In this case study, Shanghai Henli…
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
A major advantage of SPR-based analysis is its ability to estimate the association and dissociation rate constants, an …
Article
The Challenge of Disruptive Technologies in Bioprocessing
Demand for mAbs, for example, is expected to increase by one or two orders of magnitude, and it may not be economical to cover this demand increase using current bioprocessing technology, according to…
Article
Multidimensional Scale-Up of a Monoclonal Antibody Capture Step, Using ÄKTA™ pilot 600
The process, performed with MabSelect™ PrismA Protein A chromatography resin, was scaled up 20-fold from a 70 mL HiScale™ 26 column to a 1400 mL AxiChrom™ 100 column. Equivalent mAb recovery and purit…
Poster
A Next Generation Protein A Chromatography Resin for Improved Productivity and Bioburden Control
This poster presents a newly designed, high-capacity Protein A resin, MabSelect™ PrismA, which offers alkali stability on par with ion exchange and hydrophobic interaction chromatography resins, enabl…
Article
How to Address Bioburden Challenges: Insights and Tips
Another important area where suppliers can contribute is sanitization and storage procedures for protein A chromatography resins, which are widely used to purify mAbs.
Learn more about insights an…
Poster
Impact of sporicidal agent on MabSelect SuRe™ protein A resin lifetime
In this application note, the effects of treating MabSelect SuRe protein A affinity resin with 20 mM PAA every fourth process cycle for more than 100 cycles were investigated. The results show that t…