Search results for " connected" in Articles / App Notes
Article
Automated In-Line Buffer Preparation from Ready-Made Stock Solutions in a mAb Process Step
To further reduce the time and space required, ready-made stock solutions delivered in disposable bags were connected directly to the Inline Conditioning system and feedback regulation of the final bu…
Article
Unifying Continuous Biomanufacturing Operations
The success of a truly integrated continuous processing platform relies on the collaborative efforts of upstream and downstream specialists.
By Randi Hernandez
When human cells travel throug…
Article
Fusion Proteins Pose Manufacturability Challenges
The unique structures of fusion proteins lead to expression, heterogeneity, and stability issues.
By Cynthia A. Challener
Fusion proteins are engineered proteins that contain domains from di…
Article
Witnessing Major Growth in Next-Generation Antibodies
For instance, for bispecifics consisting of multiple heavy and light chains, it is essential to ensure that the right components are connected together, according to de Fougerolles. The synthesis of t…
Article
Mechanistic Modeling of Preparative Ion-Exchange Chromatography
Step 2: Estimation of column flow parameters
Once system parameters are estimated, a packed column of a bed height of 5 cm can be connected. Protein samples then can be injected with high Na+ …
Article
Single-use Bioreactors Have Reached the Big Time
The decision to use disposable bioreactors is now driven by commercial rather than technological considerations.
By Cynthia A. Challener
Single-use bioreactors available from various vendors…
Article
Efficient concentration of a low-titer bovine IgG with high recovery in low volume
This application note describes the design of circuits with low working volume, allowing for high concentration of dilute feed streams. The use of ReadyCircuit™ single-use assemblies allowed for as…
Article
Evaluating E&L Studies for Single-Use Systems
Extraction studies demonstrate approaches for evaluating single-use bio-pharmaceutical manufacturing materials.
By Irene Cecchini, Daniele Mastroianni, Silvia Rocchi, Gabriella Angiuoni
Biop…
Article
Process Chromatography Selection for Downstream Processing Applications
For the same reasons, processing in which multiple unit operations are connected without any hold tanks can help to alleviate storage issues.
Companies must plan for liquid consumption and waste. …
Article
Perfusion in the 21st Century
Quality, flexibility, and cost savings are driving use of perfusion technology in biosimilars manufacturing.
By Bruce Lehr, Delia Lyons
Cell-culture technology for biopharmaceutical manufact…