Search results for " process"
Article
Raw Material Variability: The Need for Deeper Process Understanding
However, the increased molecular diversity and drive for higher productivity brings new challenges for process developers. One of these challenges is how to get deeper understanding for sources of var…
Article
Getting it Right from the Start in the Drug Development Process
Both upstream processing and downstream processing can affect critical quality attributes of the drug molecule under development. These effects can result in process-related impurities, product impuri…
Poster
A Scalable Adenovirus Production Process, from Cell Culture to Purified Bulk
In this study, we have combined technical evaluation of process steps and process economy calculations, from AdV production in cell culture to purified bulk product in up to 10 L scale. Human AdV5, ex…
Poster
Perfusion Media Development for Scalable Processes
Optimized processes at low CSPR drastically reduce equipment costs, lab space, and product dilution. Finally, operating at very low CSPR will allow for mammalian cell bioprocesses to run as true chemo…
Poster
To Speed Up the Process Optimization of the Described Biosimilar Product
This example describes a standardized workflow using a highthroughput process development (HTPD) approach: chromatography resin and running conditions were selected based on experience and adapted to …
Article
Single-Step, Protein A Chromatography Process for Bispecific Antibodies in Early Screening
BsAb constructs were efficiently purified to give more than 90% purity and 85% yield in the early screening downstream process.
Learn more about bispecific purification
Poster
High-Throughput Downstream Processing Using Cellulose Fiber Chromatography and ÄKTA™ Chromatography Systems
The novel cellulose fiber technology (known as Fibro) may be used with ÄKTA chromatography systems and autosamplers to reduce process time significantly compared with conventional chromatography.…
Article
Process Economy Simulations on a Protein A Capture Step
This application note gives calculation examples that highlight scenarios where the enhanced capacity and alkaline‐stability of MabSelect PrismA can provide process economic benefits to large‐scal…
Poster
Residual DNA analysis in influenza vaccine processing
To reliably measure residual DNA in both process samples and final vaccine by quantitative PCR (qPCR), DNA preparation prior to analysis is a necessity. Samples from the vaccine purification process c…
Article
Single-Use and Continuous Processing Technologies Change Facility Design
In parallel, another change on the horizon in biopharmaceutical plants is continuous processing--the impact of which could be as significant in the pharmaceutical industry as it was in the car and ele…