Search results for "chromatography" in Articles / App Notes
Article
Cytiva expanding US operations
Cytiva, a global life sciences leader, is investing in additional resins manufacturing operations outside of Sweden, for the first time in the company’s history, with the acquisition of a …
Article
Developing a Robust Bioprocess Using Mechanistic Models
The safety and efficacy of a biopharmaceutical drug are of the highest priority. Therefore, manufacturers have to design, implement and maintain measures to ensure that the bioprocess con…
Article
Accelerating VLP purification process development
See how using mechanistic modeling can speed up the purification process development of virus-like particles (VLPs).
Indeed, a method for the large-scale production of VLPs is produ…
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e-Learning: what is quality by design (QbD)?
This free interactive course shares what quality by design (QbD) is all about. The focus lies on applying QbD to process development of biopharmaceuticals.
Key learnings:
- Fundamen…
Article
Advanced therapeutics process development using mechanistic modeling
Guterstam
Watch the interview of Peter Guterstam and Nick Whitelock (Cytiva), and learn about
the biological background of advanced therapeutics
what mechanistic modelling …
Article
Virus and exosome purification: harness core bead technology
Using core bead technology to fine tune impurity removal and maximize recovery of
large entities.
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Article
Engage a mechanistic modeling expert – or become one
The application of mechanistic modeling requires expertise for effective use. When planning to implement this ground-breaking technology one essential question must be addressed befor…
Article
Mechanistic vs Statistical Models
Mathematical models are recommended by the ICH Q8 guidelines on pharmaceutical development to generate enhanced process understanding and meet Quality-by-Design (QbD) guidelines. Read on the d…
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Analytical Considerations for Successful Upstream Process Development with Spivey and Lane
… variation in the glycosylation pattern, then folks are going to say, “I can't clean this up with chromatography in the downstream step. We have to go back to the beginning, get better control over t…
Article
Implementing Inline Conditioning to Advance Process Intensification
With inline conditioning buffers can be prepared inline from buffer concentrates or stock solutions, and directly integrated with the chromatography or filtration step. This eliminates the need for in…