Search results for "chromatography" in Articles / App Notes
Article
Report from the 6th International HTPD Conference
HTPD was mainly limited to 96-well plates filled with chromatography resins used for resin selection and initial screening of running conditions. Since then, HTPD in chromatography applications has be…
Article
Biomanufacturing: Demand for Continuous Bioprocessing Increasing
Multi-column, countercurrent, and other variations of continuous chromatography units are just starting to enter the market. The classic and still predominant approach to bioprocessing, both upstream …
Article
2019’s Top Bioprocessing Trends and What to Expect in 2020
Readers were particularly interested in learning how Fibro technology can be used in conjunction with ÄKTA™ chromatography systems and autosamplers to reduce process time significantly when compa…
Article
Addressing the Complex Nature of Downstream Processing with QbD
“Polishing steps such as ion exchange, hydroxyapatite, and hydrophobic interaction chromatography can be more heavily influenced by pH, conductivity, loading capacity, residence time, and temperature,…
Article
Getting a Handle on Biopharma’s Most Critical Quality Attributes and Quality Control
Conventionally, methods that include peptide mapping, N-glycan analysis, capillary electrophoresis (CE), ion exchange chromatography, reversed-phase ultra-high-performance liquid chromatography (RP–UH…
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Modeling the Degradation of mAb Therapeutics
In brief, buffers examined included those commonly used for Protein A chromatography, cation exchange chromatography, and anion exchange chromatography.
Samples were kept at three different te…
Article
Integrated Semi-Continuous Process for mAb Production
…processes typically deals with single unit operations, such as perfusion cell culture or continuous chromatography. Examples where two or more unit operations are connected and integrated are, theref…
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From Darwin to Recombinant Fc Multimers
Damien Bataille from LFB presented how affinity chromatography with a novel chromatography resin, VIISelect, together with a QbD approach, delivered a robust process control strategy to deliver a high…
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Unifying Continuous Biomanufacturing Operations
Downstream continuous purification has seen some success as well, mostly through the integration of various chromatography column sequences. But the continuous production of biologics in a closed, tot…
Article
Protein Purification Troubleshooting Guide
Practical advice to significantly impact your chromatography workflow
Put this poster on your lab wall to quickly identify and resolve protein purification problems when and where they happen. I…