Search results for "Mab" in Articles / App Notes
Article
Innovative Chromatography Resins Can Improve Purity and Quality
With ongoing efforts to increase monoclonal antibody (mAb) productivity in large-scale biomanufacturing, biomanufacturers continuously seek advancements in downstream processing technologies, with dow…
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Single-Use for Downstream Chromatography: Benefit or Hindrance?
In traditional industrial mAb processes, large volumes of both chromatography resin and buffer are required, which translates into high operating expenses. Because chromatography resins make up a larg…
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Challenges in Cell Harvesting Prompt Enhancements
The higher titers and cell densities made the initial clarification of monoclonal antibody (mAb) product more difficult, driving the need for filtration technologies that can handle the large amounts …
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Cost Considerations Drive Lean Technology in Biopharmaceutical Manufacturing
FDA approved the first Humira (adalimumab) biosimilar, Amjevita (Amgen), in September 2016, and it was the fourth biosimilar approved in the United States. The European Medicines Agency (EMA) started …
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Ligand-Binding Assays and the Determination of Biosimilarity
For monoclonal antibodies (mAbs), which make up a large portion of the biosimilars currently under development, it is important to remember that the different ends of the molecule are involved in bind…
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Single-Domain Antibodies for Brain Targeting
Going single domain
Biologic therapies such as monoclonal antibodies (mAbs) are enabling the targeted, personalized treatment of cancer, inflammatory diseases, infectious diseases, and diseases of…
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Digitalization: The Route to Biopharma 4.0
In the biopharma industry, distributed control system (DCS) and programmable logic controller (PLC) with SCADA system are two of the commonly used automation platforms. DCS has centralized set point m…
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As the therapeutic pipeline diversifies, chromatography toolboxes are expanding.
For traditional mAbs, protein A chromatography is used to capture antibodies. Depending on the structure of the target antibody and the impurity profile, other affinities, like protein L or variants o…
Article
Top Process Development Trends for 2021 and a Look into 2022
…here has been a significant increase in titers of bioprocess, especially for monoclonal antibodies (mAbs). In the 1980s and 1990s, mAb titers were only 0.5 g/L. From the 1990s onward, the average mAb…
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Updating Viral Clearance for New Biologic Modalities
For traditional downstream processing templates, such as monoclonal antibody (mAb) purification, the technologies used to ensure virus removal are well established and their effectiveness has been con…