Search results for "Mab" in Articles / App Notes
Article
Cleaning Protein A Resins with 1 M NaOH
Download application note
For more information, visit MabSelect Protein A resins
Article
Reducing Cross-Contamination Risks in Process Chromatography
Preferred target molecules
A variety of biologics benefit from the use of disposable technology in their production, from monoclonal antibodies (mAbs) and recombinant medicines to vaccines and…
Article
Downstream Processing for Cell-Based Therapies
Unlike the traditional manufacture of monoclonal antibodies (mAbs) and other biologics, the production and processing of cellular material forms the basis of the product for CGTs (1). As such, manufac…
Article
Single-use Bioreactors Have Reached the Big Time
“Examples include traditional vaccines and blockbuster [monoclonal antibody] (mAb) biologics (>2 metric tons of mAb per year); in these cases, single-use bioreactors might not be the most efficient pr…
Article
Walk Away and Do More Screening Preps
Learn how an ÄKTA pure protein purification system can be modified to increase throughput of mAb purifications and decrease hands-on time.
Article
Fed-batch supplements to boost cell culture performance
This application note demonstrates the enhanced performance of commonly used cell lines for MAb production when supplemented with HyClone™ cell culture supplements. Cultures of Chinese hamster ovary (…
Article
Best Practices in Qualification of Single-Use Systems
Figure 1 depicts a typical monoclonal antibody (mAb) drug manufacturing process. Single-use bioreactors are widely used in cell line expansion, and the use at production scale is increasing, notably i…
Article
Use of Multivariate Data Analysis in Bioprocessing
Figure 4: A) Typical platform process for mAb production. B) (B1)Application of multivariate data analysis (MVDA) for establishing process comparability across lab and production scale. (B2) PLS–DA VI…
Article
Tackling Analytical Method Development for ADCs
Capillary isoelectric focusing (cIEF), such as imaged cIEF, has been a reasonable substitute, but experience with monoclonal antibodies (mAbs) suggests that there may be differences in the information…
Article
High-Throughput Process Development in an Historical Environment
…es and different formats were used to identify the effect of ligand density in monoclonal antibody (mAb) purifications. Two different novel multimodal polishing Capto™ ImpRes resins were evaluated an…