Search results for "Mab"
Article
Use of Multivariate Data Analysis in Bioprocessing
Figure 4: A) Typical platform process for mAb production. B) (B1)Application of multivariate data analysis (MVDA) for establishing process comparability across lab and production scale. (B2) PLS–DA VI…
Article
Tackling Analytical Method Development for ADCs
Capillary isoelectric focusing (cIEF), such as imaged cIEF, has been a reasonable substitute, but experience with monoclonal antibodies (mAbs) suggests that there may be differences in the information…
Article
High-Throughput Process Development in an Historical Environment
…es and different formats were used to identify the effect of ligand density in monoclonal antibody (mAb) purifications. Two different novel multimodal polishing Capto™ ImpRes resins were evaluated an…
Article
Continued Process Verification for Biopharma Manufacturing
Its recommendations are based on a typical cell culture production process for making a fictitious monoclonal antibody (mAb) product (3). Although this model plan does not provide examples of all aspe…
Article
Concentrating Feed—an Applicable Approach to Improve Antibody Production
Feed-volume reduction can also reduce the cost of consumables, such as disposable bags and medium storage space. Because the feed dilutes the culture and reduces product concentration, the use of lowe…
Article
2014 Manufacturing Trends and Outlook
…of the respondents reported that their organizations manufacture therapeutic monoclonal antibodies (mAbs); more than 55% of those surveyed said they manufacture protein-based drugs other than mAbs. M…
Article
Optimizing KiH bispecific antibody chromatography steps
However, due to their increased complexity bsAbs often have higher levels of impurities in comparison to monoclonal antibodies (mAbs). This presents challenges to downstream processing.
This web a…
Article
Selected courses from cell culture and downstream process development to scale-up and manufacturing
…ine development
Bioreactor scaling
Filtration in bioprocessing
Purification of mAb variants
DoE in protein purification
Browse our catalog of free eLearning course…
Article
Buffer optimization for separation of bsAb in a capture step using MabSelect™ VL resin
…elution pH, resolution between hetero- and homodimers for bsAb’s, and removal of light chain from mAbs during elution when using MabSelect™ VL protein L resin. The video includes results of these exp…
Webcast
Webinar: Intensifying Downstream Bioprocessing With Continuous Technologies
In this webinar we will explore common bottlenecks in downstream processing and look at continuous processing solutions that can further intensify the monoclonal antibody (mAb) platform.
We will di…