Search results for "Mab"
Article
Enhancing Resins Addresses Purification Concerns
“This has especially been true for the success of mAbs. Now, we start to see a new landscape based on a variety of new modalities such as viral vectors, mRNA, pDNA, cell and gene therapy, and oligos,”…
Article
Antibody Production Workflow
Explore the workflow here >>
Antibody-based therapies have evolved beyond monoclonal antibodies (mAbs) to include bispecific antibodies, antibody fragments, antibody-drug conjugates (ADCs), and m…
Article
Start-to-Finish Connected Manufacturing
That’s why we are demonstrating our mAb process that tested the performance of a new Xcellerex automatic perfusion system (APS) bioreactor, compared resin and fiber-based chromatography, and utilized …
Article
Platform for Purification of VHH-type Antibody Fragments
This poster shows examples of purification of mAb-derived fragments.
Article
Technology Innovations Improve Process Chromatography Performance
Deorkar also notes that there is a lack of diversity in the supply chain of Protein A resin, which is used in the first downstream chromatography step in monoclonal antibody (mAb) manufacturing. “That…
Article
Step Up to GMP Manufacturing or Outsource to a CDMO: Considerations and Tips
Whether you are developing a new monoclonal antibody (mAb), cell therapy, gene therapy, or large-molecule biologic drug, the decision to tackle GMP manufacturing in-house or work with a contract devel…
Article
Improving Upstream Predictability
“We’ve consistently been seeing titers in the range of 4–6 g/L in [monoclonal antibody] mAb fed-batch processing within a chemically defined media environment. This environment, in turn, results in mo…
Article
A New Paradigm in Process Development
Download this e-book for case studies and insights from Janssen, Roivant Sciences, and mAbxience.
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Poster
Scalable Continuous Chromatography Process for Enhanced Efficiency in Biomanufacturing
…ate that PCC is a robust and scalable technology: a 50-fold scale-up of a three-column PCC (3C PCC) mAb capture step within the lab-scale ÄKTA™ pcc system and a 294-fold scale-up directly from l…
Article
Scaling Up Novel Therapies
Used almost exclusively for monoclonal antibodies (mAbs), platforms help shorten development times, particularly early in development, Ransohoff says. They also allow manufacturers to leverage perform…