Search results for " media"
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High-Throughput Process Development Handbook
Time-to-clinic and time-to-market are two key factors for successful biopharmaceutical development. Efficient development of the manufacturing process is a crucial component of the overall project…
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Generating a Fully Processed Antibody
Also recently, the FGE enzyme was shown to require copper (II) for full activity (6, 7), so supplementation of copper (II) sulfate to the media optimizes amino acid conversion.
Cell-line engineeri…
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Affinity chromatography Handbook - Vol. 3: Specific Groups of Biomolecules
This volume of the Affinity Handbook describes the role of AC in the purification of specific groups of biomolecules, the principle of the technique, the chromatography media available and how to sele…
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Managing Biomanufacturing Capacity Expectations
Despite these benefits, concentrated fed-batch used more perfusion and feed media, required numerous filters, and also overloaded downstream processes, causing filter fouling in some cases. The yields…
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A Q&A on Bioprocessing Trends and Technologies at INTERPHEX 2016
Did you see any trends in the consumables segment?
The quality and supply of cell-culture media, buffers, and other process liquids was also a popular topic. Demand for custom formulations and pac…
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Lessons Learned Accelerate Vaccine Development
High-throughput and single-use technologies are also being leveraged to accelerate key aspects of manufacturing processes, such as determination of appropriate media, resins for purification, formulat…
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A Risk-Based Genetic Characterization Strategy for Recombinant CHO Cell Lines Used for Clinical and Commercial Applications
Changes in media components and growth conditions often result in changes in cell culture profiles, and one should consider re-testing the integrity and stability of the expression construct at the li…
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Developing Cleaning-in-Place Protocols
Cleaning conditions for chromatography media can be screened in a couple of working days using 96-well microtitre plate formats. A study with a Protein A resin illustrates the approach in this appli…
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Selecting the Right Viral Clearance Technology
By Cynthia Challener, PhD
The introduction of adventitious viral agents is a recognized, inherent risk of biologic drug production that is well addressed by international regulatory requirements…
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CMOs Continue to Improve Overall Biomanufacturing Performance
These range from better analytical testing and product release services to better operations staff training, optimized media and improved existing quality management systems. Better process developmen…