Search results for "Recovery" in Articles / App Notes
Article
Evolution of the Monoclonal Antibody Purification Platform
Load capacity (>1500 g/L) may be achievable with > 95% product recovery and robust process performance.
Monoclonal antibodies expressed in yeast
While mammalian cells (e.g., such …
Article
Virus and exosome purification: harness core bead technology
Using core bead technology to fine tune impurity removal and maximize recovery of
large entities.
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Article
Evaluation of Fibro PrismA for Scalable Single-Use mAb Purification
The team assessed scalability from lab- to process-scale units, tracking pressure drop, step recovery, purity, and eluate volumes across multiple cycles.
Article
Technology Innovations Improve Process Chromatography Performance
“In downstream processing, the ultimate goal for biopharma manufacturers is to improve recovery and reduce the cost per gram of protein produced. Currently, over 60% of the cost to produce a new biolo…
Article
A Look at the Affinity Chromatography Landscape
A new, sulfated cellulose affinity membrane specifically designed by Sartorius for virus capture provides maximum virus access with increased selectivity and product recovery. It is useful for the cap…
Article
Downstream Processing for Cell-Based Therapies
Using TFF and EBC, Cunha and colleagues showed high protein clearance (98%), high recovery of viable hMSCs (70%) with no impact on cell viability (95%) or other CQAs (morphology, immunophenotype, prol…
Article
Microbiological Testing: Time is of the Essence
In addition, the many different matrices of the different in-process samples lead to challenges with recovery of different organisms depending on the process step,” he explains.
Next-gen therapies …
Article
A Platform Approach for the Identity Testing of Multi-Component Cell-Culture Media
Accuracy was determined by calculating the percent recovery of glucose spiked in CDS culture medium at concentrations ranging from ~50% to ~150% of the glucose concentration in each medium. The spike …
Article
Optimizing Cation-Exchange Chromatography with High-Throughput Process Development for mAb Purification
Productivity
The productivity, expressed as amount of product per unit of time and unit of chromatography media, is determined by the breakthrough capacity of the chromatography media, the recover…
Article
Host-Cell Protein Measurement and Control
FDA expects “Whenever possible, contaminants introduced by the recovery and purification process should be below detectable levels using a highly sensitive analytical method” (7). The European Medicin…