Search results for "Scale down" in Articles / App Notes

Article Adherent Cell Culture in Biopharmaceutical Applications: The Cell-Detachment Challenge
The necessity to detach cells from a culture substrate during cell harvesting remains one of the most challenging steps in a cell-culture process. By Marcos Simon, Juan J. Giner-Casares Cell…

Article SEC in the Modern Downstream Purification Process
Mar 01, 2015 By R. Christopher Manzari, J. Kevin O'Donnell BioPharm International Volume 3, Issue 28 Since the introduction of commercial chromatography resins approximately six de…

Article Automated Concentration and Diafiltration of Multiple siRNA Samples
A team of scientists collaborated on a project to transfer a conventional manual concentration/diafiltration process for siRNA production.  ABSTRACT The use of small-interf…

Article Explore ÄKTA pilot 600 in 3D
Cost and speed are critical components in biomanufacturing. See how ÄKTA pilot™ 600 supports scale-up from process development to GMP clinical scale. Explore this ÄKTA™ system in…

Article Discovering the unknown: How does in silico process development change PD scientists’ work?
In silico process development for chromatography is a paradigm-shifting approach that redefines the routine work of process development scientists. But what does it actually mean to perfor…

Article Digitalization: The Route to Biopharma 4.0
In microbial cell cultures, scale down models such as micro well plates (3) and deep well plates are employed, whereas shake tubes/flasks are widely used in mammalian cultures (4). However, most of th…

Article FAQ: Scale-up and scale-down with mechanistic modeling
A mechanistic model can simplify your process development projects. The model eases scale-up and scale-down between lab scale and production scale. To apply model-based scale-up and scale-down

Article Common Challenges in Cross-Functional Process Development
cross functional Click here to view more Industry Leader Q&As >> James Blackwell, President, Windshire Group, LLC, explores common challenges in cross-functional process developme…

Article Strategizing for Rapid Changeovers in Biologics Manufacturing
Olivier Le Moal/Stock.Adobe.com By Cynthia A. Challener  Facility and equipment design are important, but the team and its experience matter most. Through its Operation Warp Speed pro…

Article Technology Innovations Improve Process Chromatography Performance
As technology matures, inefficiencies and process limitations in downstream process chromatography are improved. By Feliza Mirasol Selecting an appropriate separation technology fo…

Show All Results

Previous PageNext Page