Search results for " platform" in Articles / App Notes
Article
Improving Upstream Predictability
…on introduce an automatic perfusion system that integrates into the company’s Xcellerex bioreactor platform to facilitate intensification during both N-1 and N stages. The company is also working to …
Article
Mapping a Route for Cell and Gene Therapy Process Development
For cell-therapy applications, Baghbaderani points to the Cocoon Platform from Lonza, an automated GMP-in-a-box concept for patient-scale cell therapy manufacturing, other iPSC platform technologies t…
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Moving PAT from Concept to Reality
This barrier is readily evident with the lack of integration into the existing process equipment installed base, automation platforms, and control strategies, adds Makowiecki. He also comments that th…
Article
Leveraging Computational Models of Glycosylation for Biopharma QA
…er ovary (CHO) and murine myeloma (NS0 and Sp2/0) cell lines being the most-commonly used production platforms (5). During cell culture, even subtle variations in nutrient availability, dissolved oxy…
Article
Real-Time Characterization of Biotherapeutics and Comparability of Biosimilars
The comparability exercise involves characterization and analysis by a platform consisting of numerous, orthogonal analytical tools (Figure 1). Failing to demonstrate similarity can come at a signific…
Article
A Look at the Affinity Chromatography Landscape
“As the complexity of the medicines in pipelines increases, so do the processes required to purify them, and these affinity resins allow platform-like approaches to novel molecular entities, reducing …
Article
Achieving Process Balance with Perfusion Bioreactors
Adams notes that the company’s single-use bioreactors for perfusion also incorporate the same sensor and software platforms provided with its stainless-steel bioreactors, allowing for the same process…
Article
The Challenge of Disruptive Technologies in Bioprocessing
Disruptive innovations
“Keeping in mind the trends mentioned, there is a focus to improve productivity and have platformable processes for these new modalities, while meeting the high quality and …
Article
Biopharma Seeks Balance
…, next-generation sequencing, continuous manufacturing for downstream processes, and a manufacturing platform for continuous bioprocesses (2).
New challenges to manufacturing
Manufac…
Article
Fifteen Years of Progress: Biopharmaceutical Industry Survey Results
As discussed in the current annual report, companies prefer to concentrate on one or a few platforms to be applied to as many products as possible. Most have or are moving to adopt mammalian systems a…