Search results for "antibody" in Articles / App Notes
Article
Innovative Chromatography Resins Can Improve Purity and Quality
With ongoing efforts to increase monoclonal antibody (mAb) productivity in large-scale biomanufacturing, biomanufacturers continuously seek advancements in downstream processing technologies, with dow…
Article
Strategies and Emerging Technologies for mAb Capture
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In this webinar, we will describe and evaluate different process intensification strategies for the monoclonal antibody (mAb) capture step. Strategies wi…
Article
Sanitization Opportunities for Protein A Resins
Here, we describe an approach to safely sanitize our new generation bioprocess protein A affinity resin for antibody purification—MabSelect PrismA—with 30 mM PAA combined with NaOH cleaning-in-place r…
Article
Genetic Vaccine Platforms Demonstrate Their Potential
Other cancer and T-cell vaccine are in development to treat antibody evasive viruses, and existing vaccines are being re-developed to provide better protection and coverage.
“Ongo…
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Remote Monitoring and Big Data Advance Upstream Automation
New therapeutic modalities, most notably personalized medicines, also present unique automation challenges that cannot be solved using more traditional batch monoclonal antibody automation systems. “L…
Article
Developing a Closed, Connected Single-Use mAb Purification Process
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Learn more on this case study to set up a closed and connected single-use monoclonal antibody (mAb) purification process that addresses a perfusion upstream process. In the Pr…
Article
Biacore SPR Technology Applied to Precision Diagnostics
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Read this overview of Biacore™ surface plasmon resonance (SPR), a diagnostic tool to aid and simplify immunoassay reagent selection and accelerate the development of fit-for-purpose d…
Article
Process Development: 2020 Reflections and 2021 Possibilities
The challenges posed by the COVID-19 pandemic in 2020 brought about many unprecedented lessons and promising developments in the biopharmaceutical industry. Last year in particular reenforced the ne…
Article
Improving mAb Manufacturing Productivity by Optimizing Buffer and Media Prep Process Flow
A typical monoclonal antibody (mAb) process may require 2000 L of a buffer and more than 100,000 L per batch based on titer and bioreactor volume (1, 2). As a result, the variety of buffer solutions u…
Article
Eliminating Residual Impurities Starts with a Strategic Plan
Eliminating Residual Impurities Starts with a Strategic Plan
Identifying the source, assessing the risk, and removing residual impurities requires a strategic approach.
By Cynthia A. Ch…