Search results for "antibody" in Articles / App Notes
Article
Report from the 6th International HTPD Conference
One of the challenges they saw, was that the models are based on historical datapoint, predominantly mAbs, and the future pipeline is more diversified with several types of antibody variants.
An…
Article
A Look into Biologic Scale-Up Strategies
Optimizing cell-culture processes for monoclonal antibody (mAb) production is a key factor in scaling up manufacturing to commercial levels. To maximize cell-culture output, strategy is requir…
Article
Fundamentals of hydrophobic interaction chromatography
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* recombinant proteins and peptides
* monoclonal antibodies (mAbs), bispecific mAbs and antibody-drug conjugates (ADC)
* mRNA
* plasmid
New to HIC? Browse this HIC resource li…
Article
Developing a HIC polishing step for removal of mAb aggregates
This article describes the development of a flow-through (FT) polishing step using hydrophobic interaction chromatography (HIC) to remove mAb aggregates.
It includes:
- The use of HTPD plate…
Article
How to program, run and evaluate a design of experiments (DoE)
An application example showcases how to optimize an antibody purification for low dimer-and-aggregate and host cell proteins (HCPs) content while achieving best possible yields.
Take the course now…
Article
Visualize the Xcellerex™ X-platform bioreactors in 3D
Bioreactors are integral to the manufacture of protein-based drugs, especially monoclonal antibodies. Xcellerex™ X-platform bioreactors from Cytiva are designed to meet process needs of today …
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Protein L affinity resin is ready to move to manufacturing
Although protein L affinity resins have been available for more than a decade, insufficient binding capacities and alkaline stability challenges have limited their use in productive manufactur…
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What is process development?
Biopharma process development comprises the activities that help you create a series of steps to produce a biomolecule – a monoclonal antibody (mAb), recombinant protein, viral vector, or other produc…
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Top Process Development Trends for 2022 and a Look into 2023
The article, “Next-generation Protein L Chromatography,” for example, begins by establishing that the diversity of antibody variants in today’s pipeline presents unique challenges for purification pro…
Article
Report from the 12th Plasma Product Biotechnology Forum
Since the first meeting in 1999, the PPB forum has established itself as the key international forum for the plasma manufacturing industry – read our report for the highlights of the 2022 conference…